B Type Natriuretic Peptide (BNP)

Message

Performing Lab: RHP for HP Clinic sites
Performing Lab: Lakeview for CC/MH/SS sites
Performing Lab: St Cloud
Performing Lab: Hudson
Performing Lab: Westfields

Test Code

3710

Alias/See Also

Sunquest: BNP; Brain Natriuretic Peptide, Natriuretic Peptide

CPT Codes
83880

Preferred Specimen

0.5 mL White PPT (EDTA Plasma) tube

Minimum Volume

0.2 mL

Other Acceptable Specimens

EDTA plasma (lavender-top) tube
EDTA plasma (pink-top) tube

Instructions

White PPT (EDTA Plasma) tube, spin and send.
EDTA lavender-top or pink-top tubes spin, aliquot and send.

Transport Temperature

Refrigerated

Specimen Stability

Room Temperature: 4 hours (separated plasma)
Refrigerated: 24 hours (separated Plasma)
Frozen: Indefinite (Separated plasma)

Methodology
Fluorescence Immunoassay

Setup Schedule

Daily

Report Available

Same day.

Reference Range

<100 pg/mL

Clinical Significance

BNP is one of three natriuretic peptides. Atrial natriuretic peptide (ANP) and BNP originate in the cardiac myocytes. C-type natriuretic peptide (CNP) originates in the endothelial cells. These peptides regulate blood pressure, electrolyte balance and fluid volume. Primarily the left ventricle in response to pressure and stretch produces BNP. BNP functions to counteract the vasoconstrictive effects of the renin-angiotensin aldosterone system on increasing blood pressure and retaining salt and water. Because of BNP’s short half-life, approximately 20 minutes, and its rapid clearance from circulation, BNP measurements correlate well with ventricular functional status.

Heart failure or congestive heart failure (CHF), when patients experience a buildup of fluid, is a clinical symptom characterized by shortness of breath, fatigue and peripheral edema caused by the heart’s inability to adequately circulate blood to the body’s essential organs. BNP levels increase with decreasing left ventricular function and increasing clinical severity of heart failure. Therefore BNP can be used for both the diagnosis and monitoring of patients with heart failure.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.