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Vancomycin
MessagePerforming Lab: Hudson, Lakeview, Regions, Westfields
Test Code
RH9025
Alias/See Also
Sunquest: VANCO, Vancocin
CPT Codes
80202
Preferred Specimen
0.2 mL Lithium heparin plasma (light green-top) tube
Minimum Volume
0.1 mL
Other Acceptable Specimens
Gold, Red, Red/Gray
Instructions
Trough drug monitoring should begin after steady state is achieved and samples should be collected within 30 minutes of the next dose. When peak levels are being measured, samples should be drawn 0.5-2 hours after infusion.
Centrifuge specumens and remove from cellular material within 4 hours. Protect from light after collection.
Centrifuge specumens and remove from cellular material within 4 hours. Protect from light after collection.
Transport Temperature
Refrigerated
Specimen Stability
Room Temperature: 2 hours
Refrigerated: 3 days
Frozen :14 days
Refrigerated: 3 days
Frozen :14 days
Methodology
Colorimetric
Setup Schedule
Daily
Report Available
Same Day
Reference Range
| Trough | Peak | Critical | |
| 10.0-20.0 mcg/mL | 20.0-40.0 mcg/mL | >59.9 mcg/mL | |
Clinical Significance
Vancomycin is used in the treatment of serious or severe infections caused by gram-positive organisms resistant to penicillins, cephalosporins, or other antimicrobial agents. It is also used in the treatment of antibiotic-associated pseudomembranous colitis produced by Clostridium difficile. The risk of ototoxicity and nephrotoxicity is increased in patients with impaired renal function, and in patients receiving concurrent aminoglycoside treatment.
Vancomycin measurements are used in the diagnosis and treatment of vancomycin overdose and in monitoring levels of vancomycin to ensure appropriate therapy. Trough drug monitoring should begin after steady state is achieved and samples should be collected within 30 minutes of the next dose.
When peak levels are being measured, samples should be drawn 0.5–2 hours after an infusion.
Vancomycin measurements are used in the diagnosis and treatment of vancomycin overdose and in monitoring levels of vancomycin to ensure appropriate therapy. Trough drug monitoring should begin after steady state is achieved and samples should be collected within 30 minutes of the next dose.
When peak levels are being measured, samples should be drawn 0.5–2 hours after an infusion.
