Total Protein, CSF

Message

Performing Lab: Hudson, Lakeview, Regions, Westfields

Test Code

3347

Alias/See Also

Sunquest: CSFTP

CPT Codes
84157

Includes

Source, CSF Total Protein

Preferred Specimen

0.2 mL CSF

Minimum Volume

0.1 mL

Instructions

Processing:
Centrifuge specimens containing cells at room temperature. Aliquot and store refrigerated.

Transport Temperature

Refrigerated

Specimen Stability

Room Temperature: 4 hours
Refrigerated: 3 days
Frozen: 6 months

Methodology
Colorimetric

Setup Schedule

Daily

Report Available

Same day.

Reference Range

12 - 60 mg/dL

Clinical Significance

Cerebrospinal fluid (CSF) proteins are those that remain in CSF following the ultrafiltration of plasma through the choroidal capillary wall. Some proteins that are unique to CSF are synthesized in the central nervous system.
In general, diseases that interrupt the integrity of the capillary endothelial barrier lead to an increase in total CSF protein.
CSF protein is generally increased in all types of meningitis, cerebral infarction, brain abscess, meningovascular syphilis, subarachnoid hemorrhage, some brain tumors, trauma to the brain, some cases of multiple sclerosis, encephalomyelitis, and degenerative neurologic diseases.
A decreased CSF protein may occur in water intoxication, CSF leak (CSF rhinorrhea or otorrhea), and hyperthyroidism.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.