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Parathyroid Hormone, Intact (IPTH)
MessagePerforming Lab: Hudson, Regions
Test Code
3792
Alias/See Also
Sunquest: IPTH; Whole Parathyroid Hormone, PTH
CPT Codes
83970
Preferred Specimen
0.5 mL Lithium Heparin Plasma (light green-top) tube
Minimum Volume
0.3 mL
Other Acceptable Specimens
Serum (gold-top, red-top, red/gray-top), Lithium Heparin (light green-top) on ICE
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 2 days
Frozen: 1 month
Frozen: 1 month
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis, Lipemia
Methodology
Immunometric
Setup Schedule
Daily
Report Available
Same day
Reference Range
10 - 100 pg/mL
Clinical Significance
The primary role of PTH is to maintain calcium homeostasis via its interaction with calcitonin. PTH measurement is an important aid in the diagnosis of disorders of calcium metabolism. PTH synthesis and secretion are triggered rapidly by low concentrations of ionized calcium (Cai). The biological activities of PTH are to increase absorption of dietary calcium, decrease renal clearance and mobilize skeletal calcium stores. Abnormally high Cai concentrations suppress secreation of PTH. In conjuction with serum calcium levels, the PTH assay may be used as an aid in the differential diagnosis of hyercalcemia, hypocalcemia and parathyroid disorders. PTH determination is important in monitoring dialysis patients to manage renal osteodystrophy.
The use of intraoperative parathyroid hormone testing is recommended for patients during surgery for hyperparathyroidism, especially in minimally invasive or directed procedures, as well as for patients undergoing reoperation. For patients undergoing parathyroidectomy it is recommended that preoperative and pre-exicision samples are taken. Samples should also be drawn at 5 and 10 minutes post resection and a >50% reduction in PTH levels from the highest baseline may be used as criteria for surgical success.
The use of intraoperative parathyroid hormone testing is recommended for patients during surgery for hyperparathyroidism, especially in minimally invasive or directed procedures, as well as for patients undergoing reoperation. For patients undergoing parathyroidectomy it is recommended that preoperative and pre-exicision samples are taken. Samples should also be drawn at 5 and 10 minutes post resection and a >50% reduction in PTH levels from the highest baseline may be used as criteria for surgical success.
