| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Parathyroid Hormone, Intact (IPTH) with Calcium
MessagePerforming Lab: Hudson, Regions
Test Code
3791
Alias/See Also
Sunquest: IPTHC; Whole Parathyroid Hormone, PTH, IPTH with Calcium
CPT Codes
83970, 82310
Includes
Parathyroid Hormone, Intact (IPTH); Calcium
Preferred Specimen
0.5 mL Lithium Heparin Plasma (light green-top) tube
Minimum Volume
0.3 mL
Other Acceptable Specimens
Serum (gold-top, red-top, red/gray-top), Lithium Heparin (light green-top) on ICE
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 2 days
Frozen: 1 month
Frozen: 1 month
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis, Lipemia
Methodology
Immunometric (IPTH), Colorimetric (Calcium)
Setup Schedule
Daily
Report Available
Same day
Reference Range
IPTH:
10 - 100 pg/mL
Calcium:
8.4 - 10.2 mg/dL
Critical Low: <= 6.6 mg/dL
Critical High: >= 12.9 mg/dL
10 - 100 pg/mL
Calcium:
8.4 - 10.2 mg/dL
Critical Low: <= 6.6 mg/dL
Critical High: >= 12.9 mg/dL
Clinical Significance
The primary role of PTH is to maintain calcium homeostasis via its interaction with calcitonin. PTH measurement is an important aid in the diagnosis of disorders of calcium metabolism. PTH synthesis and secretion are triggered rapidly by low concentrations of ionized calcium (Cai). The biological activities of PTH are to increase absorption of dietary calcium, decrease renal clearance and mobilize skeletal calcium stores. Abnormally high Cai concentrations suppress secreation of PTH. In conjuction with serum calcium levels, the PTH assay may be used as an aid in the differential diagnosis of hyercalcemia, hypocalcemia and parathyroid disorders. PTH determination is important in monitoring dialysis patients to manage renal osteodystrophy.
The use of intraoperative parathyroid hormone testing is recommended for patients during surgery for hyperparathyroidism, especially in minimally invasive or directed procedures, as well as for patients undergoing reoperation. For patients undergoing parathyroidectomy it is recommended that preoperative and pre-exicision samples are taken. Samples should also be drawn at 5 and 10 minutes post resection and a >50% reduction in PTH levels from the highest baseline may be used as criteria for surgical success.
Calcium is the major mineral component of bone; 99% of the body’s calcium is in bone. Calcium ions play an important role in the transmission of nerve impulses and in maintaining normal muscle contraction. Abnormal concentrations of serum calcium may indicate malfunction of the parathyroid glands, bone diseases, carcinoma, malnutrition and malabsorption syndrome, vitamin D deficiency, overdose with calcium-containing antacids, and renal diseases.
The use of intraoperative parathyroid hormone testing is recommended for patients during surgery for hyperparathyroidism, especially in minimally invasive or directed procedures, as well as for patients undergoing reoperation. For patients undergoing parathyroidectomy it is recommended that preoperative and pre-exicision samples are taken. Samples should also be drawn at 5 and 10 minutes post resection and a >50% reduction in PTH levels from the highest baseline may be used as criteria for surgical success.
Calcium is the major mineral component of bone; 99% of the body’s calcium is in bone. Calcium ions play an important role in the transmission of nerve impulses and in maintaining normal muscle contraction. Abnormal concentrations of serum calcium may indicate malfunction of the parathyroid glands, bone diseases, carcinoma, malnutrition and malabsorption syndrome, vitamin D deficiency, overdose with calcium-containing antacids, and renal diseases.
