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Haptoglobin
MessagePerforming Lab: Regions
Test Code
0501
Alias/See Also
Sunquest: HAPTO
CPT Codes
83010
Preferred Specimen
0.5 mL Serum Separator (gold-top) tube
Minimum Volume
0.2 mL
Other Acceptable Specimens
Red, Red/Gray, Lithium Heparin (green top)
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 7 days
Frozen: 2 months
Frozen: 2 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis
Methodology
Turbidometric
Setup Schedule
Daily
Report Available
Same day.
Reference Range
35 - 250 mg/mL
Clinical Significance
Haptoglobin is an acute phase reactant. This term refers to proteins whose serum concentrations rise significantly during acute inflammation due to causes including surgery, myocardial infarction, infections and tumors. Haptoglobin binds free hemoglobin in plasma. The hemoglobin/haptoglobin complexes are removed from the circulation by the reticulo-endothelial system. Decreased Haptoglobin concentrations are generally indicative of erythrocyte destruction. Levels of Haptoglobin may appear increased in conditions of burns and nephrotic syndrome when large amounts of fluid and lower-molecular weight plasma proteins have been lost.