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Fetal Fibronectin
MessagePerforming Lab: Hudson, Lakeview, Regions, Sartell
Test Code
3669
Alias/See Also
Sunquest: FFN; Rapid Fetal Fibronectin
CPT Codes
82731
Includes
Fetal Fibronectin, Weeks Gestation
Preferred Specimen
Cervicovaginal secretions - Swab
Instructions
Collection:
Requires the Hologic Fetal Fibronectin Collection Kit that includes Dacron swab and buffer transport tube. For an asymptomatic woman, during a sterile speculum examination, insert the Dacron swab into the vagina and lightly rotate across the posterior fornix or around the ectocervical region of the external cervical os for about 10 seconds to absorb the cervicovaginal secretions. Carefully remove swab and place into buffer tube provided. Do not contaminate swab with lubricants, soaps, creams or disinfectants. For symptomatic woman, only sample from the posterior fornix.
Specimen should be obtained prior to digital cervical examination or vaginal probe ultrasound examination as manipulation of the cervix may cause the release of fetal fibronectin. Specimen should not be collected after microbial culture specimens.
Requires the Hologic Fetal Fibronectin Collection Kit that includes Dacron swab and buffer transport tube. For an asymptomatic woman, during a sterile speculum examination, insert the Dacron swab into the vagina and lightly rotate across the posterior fornix or around the ectocervical region of the external cervical os for about 10 seconds to absorb the cervicovaginal secretions. Carefully remove swab and place into buffer tube provided. Do not contaminate swab with lubricants, soaps, creams or disinfectants. For symptomatic woman, only sample from the posterior fornix.
Specimen should be obtained prior to digital cervical examination or vaginal probe ultrasound examination as manipulation of the cervix may cause the release of fetal fibronectin. Specimen should not be collected after microbial culture specimens.
Transport Container
Dacron® swab in buffer transport tube provided in the Specimen Collection Kit
Transport Temperature
Refrigerated
Specimen Stability
Lakeview, Hudson, and Regions: Room Temperature (8 hours), Refrigerated (3 days), Frozen (3 months)
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Sample prior to 24 weeks or after 35 weeks gestation; not received within 24 hours.
Methodology
Rapid Qualitative Enzyme Immunoassay
Setup Schedule
Daily
Report Available
Same day.
Limitations
Do not perform test on asymptomatic women with any of the following conditions: Multiple fetuses, partial or complete placenta previa, cervical cerclage, or sexual intercourse in the preceding 24 hours. Do not perform test on symptomatic women with any of the following conditions: Cervical dilation greater than 3 cm, ruptured amniotic membranes, moderate or gross vaginal bleeding, multiple fetuses, partial or complete placenta previa, cervical cerclage, or sexual intercourse in the preceding 24 hours.
Reference Range
Negative
Clinical Significance
The rapid fFN test is used as an aid in assessing the risk of pre-term delivery in = 7 to 14 days from the time of sample collection in pregnant women with signs and symptoms of early pre-term labor, intact amniotic membranes, and minimal cervical dilation (< 3 cm). The sample should be collected between 24 weeks, 0 days and 34 weeks, 6 days gestation.
The rapid fFN test can also be used in conjunction with other clinical information as an aid in assessing the risk of pre-term delivery in = 34 weeks, 6 days when a cervicovaginal sample is obtained during a routine prenatal visit between 22 weeks, 0 days and 30 weeks, 6 days of gestation in women with a singleton pregnancy.
The rapid fFN test can also be used in conjunction with other clinical information as an aid in assessing the risk of pre-term delivery in = 34 weeks, 6 days when a cervicovaginal sample is obtained during a routine prenatal visit between 22 weeks, 0 days and 30 weeks, 6 days of gestation in women with a singleton pregnancy.
