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DHEA Sulfate (DHEAS)
MessagePerforming Lab: Central Lab
Test Code
0472
Alias/See Also
Sunquest: DSULF; Dehydroepiandrosterone Sulfate
CPT Codes
82627
Preferred Specimen
0.3 mL Serum Separator (gold-top) tube
Minimum Volume
0.2 mL
Other Acceptable Specimens
Red, Red/Gray
Instructions
Ordering:
Adult order only, if age is <18 years see DHES
Adult order only, if age is <18 years see DHES
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Plasma is not an acceptable specimen type.
Methodology
Chemiluminescence
Setup Schedule
Monday - Friday
Report Available
Same day.
Limitations
For assays employing antibodies, the possibility exists for interference by heterophile antibodies in the patient sample. Patients who have been regularly exposed to animals or have received immunotherapy or diagnostic procedures utilizing immunoglobulins or immunoglobulin fragments may produce antibodies, e.g. HAMA, that interfere with immunoassays. Additionally, other heterophile antibodies such as human anti-goat antibodies may be present in patient samples. Such interfering antibodies may cause erroneous results. Carefully evaluate the results of patients suspected of having these antibodies.
Reference Range
Female
18–20 Years: 51 – 321 µg/dL
21–30 Years: 18 – 391 µg/dL
31–40 Years: 23 – 266 µg/dL
41–50 Years: 19 – 231 µg/dL
51–60 Years: 8 – 188 µg/dL
61–70 Years: 12 – 133 µg/dL
>70 Years: 7 - 177 µg/dL
Male
18–20 Years: 24 – 537 µg/dL
21–30 Years: 85 – 690 µg/dL
31–40 Years: 106 – 464 µg/dL
41–50 Years: 70 – 495 µg/dL
51–60 Years: 38 – 313 µg/dL
61–70 Years: 24 – 244 µg/dL
>70 Years: 5 - 253 µg/dL
No reference ranges have been established for individuals less than 18 years of age.
18–20 Years: 51 – 321 µg/dL
21–30 Years: 18 – 391 µg/dL
31–40 Years: 23 – 266 µg/dL
41–50 Years: 19 – 231 µg/dL
51–60 Years: 8 – 188 µg/dL
61–70 Years: 12 – 133 µg/dL
>70 Years: 7 - 177 µg/dL
Male
18–20 Years: 24 – 537 µg/dL
21–30 Years: 85 – 690 µg/dL
31–40 Years: 106 – 464 µg/dL
41–50 Years: 70 – 495 µg/dL
51–60 Years: 38 – 313 µg/dL
61–70 Years: 24 – 244 µg/dL
>70 Years: 5 - 253 µg/dL
No reference ranges have been established for individuals less than 18 years of age.
Clinical Significance
DHEA-S may be used in the differential diagnosis of Cushing’s syndrome. DHEA-S may also be used to evaluate adrenocortical diseases, such as congenital adrenal hyperplasia and adrenal tumors. In hirsute female patients, increased DHEA-S levels have been associated with virilizing adrenal tumors. Patients with polycystic ovary syndrome have often demonstrated elevated levels of DHEA-S, suggesting an adrenal androgen contribution to the defect in this disorder.
