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Creatinine (GFR)
MessagePerforming Lab: Central Lab, Hudson, Lakeview, Regions, Sartell, Westfields
Test Code
3711
Alias/See Also
Sunquest: GFR; Glomerular Filtration Rate, Creatinine
CPT Codes
82565
Includes
Creatinine, GFR
Preferred Specimen
0.1 mL Lithium Heparin Plasma (light green-top) tube
Minimum Volume
70 uL
Other Acceptable Specimens
Serum (gold-top, red-top, red/gray-top), Lithium Heparin (light green-top) on ICE
Transport Temperature
Refrgerated
Specimen Stability
Room Temperature (7 days), Refrigerated (7 days), Frozen (3 months)
Methodology
Enzymatic
GFR: Calculated using the CKD-EPI-eGFR equation utilizing serum Creatinine (traceable to IDMS), age, sex, and race as variables.
Setup Schedule
Hospital: Daily
Clinics: Monday - Friday
Clinics: Monday - Friday
Report Available
Same day.
Limitations
GFR and Creatinine both reported on patients >18 years
Creatinine only is reported on patients <18 years
Creatinine only is reported on patients <18 years
Reference Range
|
Gender | Age | Ref. Range | Critical |
Both | 0 - 16 years | 0.55 - 1.18 mg/dL | >=2.0 mg/dL |
Female | >=16 years | 0.55 - 1.02 mg/dL | >=7.0 mg/dL |
Male | >=16 years | 0.73 - 1.18 mg/dL | >=7.0 mg/dL |
GFR (>=20 Years): >60mL/min/1.732
Clinical Significance
Serum creatinine and urinary creatinine excretion is a function of lean body mass in normal persons and shows little or no response to dietary changes. The serum creatinine concentration is higher in men than in women. Since urinary creatinine is excreted mainly by glomerular filtration, with only small amounts due to tubular secretion, serum creatinine and a 24-hour urine creatinine excretion can be used to estimate the glomerular filtration rate.
Serum creatinine is increased in acute or chronic renal failure, urinary tract obstruction, reduced renal blood flow, shock, dehydration, and rhabdomyolysis. Causes of low serum creatinine concentration include debilitation and decreased muscle mass.
Serum creatinine is increased in acute or chronic renal failure, urinary tract obstruction, reduced renal blood flow, shock, dehydration, and rhabdomyolysis. Causes of low serum creatinine concentration include debilitation and decreased muscle mass.