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Dilute Russell's Viper Venom
MessagePerforming Lab: Regions
Test Code
3550
Alias/See Also
Sunquest: LDRVV
Includes
Reflex charge LDRC; Dil Russ Viper Venom CHARGE, if LDRVV tested.
LDRVC; Dilute Russ Viper Venom Confirm Charge, If confirmatory testing performed.
LDRVC; Dilute Russ Viper Venom Confirm Charge, If confirmatory testing performed.
Preferred Specimen
Five 3.2% Sodium Citrate Plasma (light blue-top) tubes filled to fill line of 2.7 mL per 3 mL tube
Minimum Volume
5.0 mL platelet poor plasma
Instructions
Double-spin specimen for platelet poor plasma
Transport Container
Send on Dry Ice
Transport Temperature
Frozen
Specimen Stability
Frozen: 72 hours
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Refrigerated or Room temperature >4 hours.
Hemolyzed or Clotted Samples, Samples do not meet the minimum draw requirements, Samples exceed maximum draw requirements, Samples with hematocrit >55% not collected with the special tube.
Testing must not be performed on patients receiving direct Xa inhibitors (Rivaroxiban, Xeralto, Apixaban) and/or thrombin inhibitor (Dabigatran, Pradaxa, argatroban, hirudin, lepirudin) therapy
Hemolyzed or Clotted Samples, Samples do not meet the minimum draw requirements, Samples exceed maximum draw requirements, Samples with hematocrit >55% not collected with the special tube.
Testing must not be performed on patients receiving direct Xa inhibitors (Rivaroxiban, Xeralto, Apixaban) and/or thrombin inhibitor (Dabigatran, Pradaxa, argatroban, hirudin, lepirudin) therapy
Methodology
Immuno-turbidimetric
Setup Schedule
Monday, Wednesday, Friday
Report Available
3 business days
Limitations
Prolonged DRVVT Screen and DRVVT Confirm times are obtained on plasmas from patients with factor II, V and X deficiencies as well as those on warfarin therapy. If clinically relevant, individual assays of factors II, V and X should be performed.
The Dilute Russell’s Viper Venom tests (screen and confirm) are used in conjunction with the patient’s original screening tests (PT, APTT, and TT) and possible mixing studies and STACLOTS to determine the presence of a lupus anticoagulant.
The Dilute Russell’s Viper Venom tests (screen and confirm) are used in conjunction with the patient’s original screening tests (PT, APTT, and TT) and possible mixing studies and STACLOTS to determine the presence of a lupus anticoagulant.
Clinical Significance
Lupus anticoagulants (LA’s) are autoantibodies against negatively charged phospholipid or complexes of phospholipid with either beta-2-glycoprotein or clotting factors such as prothrombin. They occur in various conditions, especially autoimmune disease. LA’s have traditionally been detected using phospholipid responsive clotting tests, such as the activated partial thromboplastin time (APTT), kaolin clotting time (KCT) and DRVVT
