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D Dimer, Quantitation
MessagePerforming Lab: Hudson, Regions, Sartell, Westfields
Test Code
3649
Alias/See Also
Sunquest: DDIQ
CPT Codes
85379
Preferred Specimen
2.7 mL (in 3 mL tube) 3.2% Sodium Citrate Plasma (light blue-top) tube filled to fill line on the tube
Minimum Volume
1.0 mL platelet poor plasma (Frozen)
Instructions
Collection: Samples with a hematocrit > 55% require a special anticoagulant adjusted tube for high hematocrits.
Processing: Freeze an aliquot of plasma at -20°C if not performed within 4 hours of collection
Processing: Freeze an aliquot of plasma at -20°C if not performed within 4 hours of collection
Transport Temperature
Room Temperature or Frozen if > 4 hours old
Specimen Stability
Room Temperature: 4 hours
Refrigerated: 4 hours
Frozen (-20C): 72 hours
Frozen (-80C): 2 Weeks
Refrigerated: 4 hours
Frozen (-20C): 72 hours
Frozen (-80C): 2 Weeks
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolyzed or Clotted Samples, Samples do not meet the minimum draw requirements, Samples exceed maximum draw requirements, Samples with hematocrit >55% not collected with the special tube.
Methodology
Immuno-turbidimetric
Setup Schedule
Daily
Report Available
Same day.
Limitations
Based on literature a normal D-dimer result (<0.50 ug/mL FEU) has a negative predictive value of approximately 95% for the exclusion of acute pulmonary embolism (PE) or deep vein thrombosis (DVT) when there is low or moderate pretest probability
Reference Range
<0.50 ug/ml FEU
Clinical Significance
On the fibrin clot plasmin degrades fibrin into various products, (i.e., D-Dimers). Antibodies specific for these products, which do not recognize fibrinogen, have been developed. The presence of these various fibrin degradation products, among which D-Dimer is the terminal product, is the proof that the fibrinolytic system is in action in response to coagulation activation
