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Coccidioides Antibody, Complement Fixation, Serum
Test Code4171
Quest Code
906
Alias/See Also
Quest 906; Sunquest: COCD
CPT Codes
86317
Preferred Specimen
1 mL serum
Minimum Volume
0.2 mL
Instructions
For CSF, use test code 5295 - Coccidioides Antibody, Complement Fixation, CSF
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Grossly icteric
Methodology
Complement Fixation (CF)
Setup Schedule
Mon, Wed, Fri, Sat
Report Available
3-6 days
Limitations
False-negatives may occur in patients with solitary pulmonary lesions. Patients with active histoplasmosis may generate cross reactions. Elevated serum antibodies may be present in patients with meningeal coccidiocomycosis.
Reference Range
<1:2 titer
Interpretive Criteria
Interpretive Criteria
| <1:2 | Antibody Not Detected |
| ≥1:2 | Antibody Detected |
Clinical Significance
Infection by Coccidioides immitis can produce a spectrum of disease, with most patients being asymptomatic and some developing disseminated disease, including pneumonia and meningitis.
Performing Laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
