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Human Placental Lactogen (hPL)
Test Code4414
Quest Code
504
Alias/See Also
Quest 504; Sunquest: HPL
CPT Codes
83632<br><strong>This test is not available for New York patient testing.</strong>
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.5 mL
Instructions
Allow blood to clot for 30 minutes. Centrifuge at 3000 RPM for 10 minutes. Separate serum and place in transfer tube. Freeze immediately at -20° C.
Note: Sex and, if pregnant, gestation period must be included with the requisition.
Note: Sex and, if pregnant, gestation period must be included with the requisition.
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
Room temperature: 4 hours
Refrigerated: 24 hours
Frozen: 90 days
Refrigerated: 24 hours
Frozen: 90 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature • Received refrigerated
Methodology
Enzyme Linked Immunosorbent Assay (ELISA)
FDA Status
The performance characteristics of the listed assay was validated by BioAgilytix Diagnostics. The US FDA has not approved or cleared this test. The results of this assay can be used for clinical diagnosis without FDA approval. BioAgilytix Diagnostics is a CLIA certified, CAP accredited laboratory for performing high complexity assays such as this one.
This test is not available for New York patient testing.
Setup Schedule
Fri
Report Available
7-14 days
Reference Range
| Males & Non-Pregnant Females | 0.00-0.10 mcg/mL |
| 1st Trimester | 0.20-2.10 mcg/mL |
| 2nd Trimester | 0.50-6.70 mcg/mL |
| 3rd Trimester | 4.50-12.80 mcg/mL |
Clinical Significance
Human placental lactogen (hPL; chorionic somatomammotropin) is a 21,000 KD polypeptide produced during pregnancy by placental trophoblastic cells. The level of hPL in maternal serum is directly related to placental function and fetal well-being.
hPL is detected at about 6 weeks after conception and its concentration increases gradually to peak levels (without decreases) until about the 34th week where it remains stable for the remainder of the pregnancy. Consistently low levels throughout pregnancy or a sudden drop in serial determinations are an indication of fetal distress. After normal delivery, the hPL concentration falls rapidly to an undetectable level.
The hPL levels in serum of women with multiple placenta pregnancies generally exceeds that of single placenta pregnancies. This is generally noted from the 2nd trimester to delivery.
hPL is detected at about 6 weeks after conception and its concentration increases gradually to peak levels (without decreases) until about the 34th week where it remains stable for the remainder of the pregnancy. Consistently low levels throughout pregnancy or a sudden drop in serial determinations are an indication of fetal distress. After normal delivery, the hPL concentration falls rapidly to an undetectable level.
The hPL levels in serum of women with multiple placenta pregnancies generally exceeds that of single placenta pregnancies. This is generally noted from the 2nd trimester to delivery.
Performing Laboratory
| BioAgilytix Diagnostics |
| 1320 Soldiers Field Road |
| Boston, MA 02135-1020 |
