Lambert-Eaton Syndrome Antibody Panel

Test Code

4559

Quest Code

11306

Alias/See Also

Quest 11306; Sunquest: LAMET

CPT Codes
86041, 86043, 86596, 86255

Includes

Acetylcholine Receptor Binding Antibody
Acetylcholine Receptor Modulating Antibody
Striated Muscle Antibody with Reflex to Titer
Voltage Gated Calcium Channel Antibody Assay

If Striated Muscle Antibody Screen is positive, then Striated Muscle Antibody Titer will be performed at an additional charge (CPT code(s): 86256).

Preferred Specimen

2 mL serum

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis • Lipemia • Icteric • Contaminated specimens • Radioactive compounds from in vivo testing • Received room temperature

Methodology
Immunoassay (IA) • Immunofluorescence Assay (IFA) • Radiobinding Assay (RBA)

FDA Status
Acetylcholine Receptor Modulating Antibody: This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Clinical Significance

Lambert-Eaton myasthenic syndrome is a paraneoplastic phenomena associated with small cell lung cancer. There is a decrease of voltage-gated calcium channels on presynaptic nerve terminals due to an auto-antibody reactive with the channels. There is an associated proximal muscle weakness and often coexisting thyroid autoimmune disease and vitiligo.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.