Catecholamines, Fractionated and Creatinine, 24-Hour Urine [39627X]

Test Code
14841

CPT Codes
82384, 82570

Includes
Creatinine, Norepinephrine, Epinephrine, Dopamine, and Total Catecholamines (calculated)

CPT code 81050 may be added at an additional charge for volume measurement

Preferred Specimen
10 mL of a 24-hour urine with 25 mL 6N HCl, submitted in a plastic, 24-hour urine container

Patient Preparation
It is preferable for the patient to be off medications for three days prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference.

Minimum Volume
5 mL

Other Acceptable Specimens
Unpreserved 24-hour urine collection with pH below 6

Instructions
Collect 24-hour urine with 25 mL of 6N HCl to maintain a pH below 3. Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen. Record 24-hour urine volume on test request form and urine vial.

Transport Temperature
Preserved: Room temperature
Unpreserved: Frozen

Specimen Stability
Room temperature: 7 days
Refrigerated: 30 days
Frozen: 49 days

Methodology
High Performance Liquid Chromatography (HPLC)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Mon-Fri a.m.; Report available: 2 days

Limitations
Recent surgery, traumatic injury, upright posture, cold, anxiety, pain, clonidine withdrawal, and concurrent acute or chronic illness may produce elevated results..

Reference Range
See Laboratory Report

Clinical Significance
The three catecholamines (norepinephrine, epinephrine, and dopamine) are the principal secretory products of neural tissue. Clinically, the measurement of circulating catecholamines is valuable in the diagnosis of catecholamine secreting tumors associated chiefly with hypertension (pheochromocytomas, neuroblastomas, and gangliomas) and with the evaluation of orthostatic hypotension.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.