Lupus Activity Panel 2

Test Code
17725


CPT Codes
86225, 86160 (x2)

Includes
DNA (ds) Antibody, High Avidity
Complement Component C3c
Complement Component C4c


Preferred Specimen
1 mL serum (x2)


Patient Preparation
Overnight fasting is preferred

Minimum Volume
0.5 mL (x2)


Instructions
Send 2 aliquots, one for dsDNA and one for the C3 and C4


Transport Temperature
Refrigerated (cold packs)


Specimen Stability
Room temperature: Unacceptable
Refrigerated: 4 days
Frozen: 21 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Grossly hemolyzed • Grossly lipemic • Heat treated • Containing visible particulate matter • Received room temperature


Methodology
Enzyme Linked Immunosorbent Immunoassay (ELISA) • Immunoturbidometry

Setup Schedule
Set up and Report available: See individual assays


Reference Range
See individual tests


Clinical Significance
In diagnosis of Lupus erythematosis, antibodies to double stranded DNA may be present and quantitation of C3 and C4 are useful to assess the formation of immune complexes and complement fixation.


Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.