VMA (Vanillylmandelic Acid), 24-Hour Urine with Creatinine [39517X]

Test Code

CPT Codes
82570, 84585


Preferred Specimen
10 mL of a 24-hour urine collected with 25 mL 6N HCl, submitted in a leak-proof urine container

Patient Preparation
It is preferable for the patient to be off medications for three days prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Patient should avoid alcohol, coffee, tea, tobacco (including use of nicotine patch), bananas, citrus fruits and strenuous exercise prior to collection.

Minimum Volume
5 mL

Other Acceptable Specimens
Unpreserved 24-hour urine with pH <6

10 mL urine: pH adjusted to < 3.0, using 6N HCl. Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen.

Transport Temperature
Preserved: Room temperature
Unpreserved: Frozen

Specimen Stability
Room temperature: 10 days
Refrigerated: 14 days
Frozen: 1 year

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
pH >3.0 • Received unfrozen

High Performance Liquid Chromatography (HPLC)

FDA Status
This test was developed and its performance characteristics were determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Mon-Fri a.m.; Report available: 2 days

Requires accurate 24-hour urine collection.

Reference Range
3-8 Years ≤2.3 mg/24 h
9-12 Years ≤3.4 mg/24 h
13-17 Years ≤3.9 mg/24 h
Adults ≤6.0 mg/24 h
Creatinine, Urine
3-8 Years 0.11-0.68 g/24 h
9-12 Years 0.17-1.41 g/24 h
13-17 Years 0.29-1.87 g/24 h
Adults 0.63-2.50 g/24 h

Clinical Significance
Urinary vanillylmandelic acid is useful in diagnosing neuroblastoma, one of the most common tumors in the pediatric population.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.