|
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Protein S Activity and Antigen, Total [7039X]
Test Code141173
CPT Codes
85305, 85306
Includes
Protein S Antigen, Protein S Activity
Preferred Specimen
1 mL (x2) plasma collected in 3.2% sodium citrate (light blue-top) tubes
Minimum Volume
0.5 mL (x2)
Instructions
Please submit a separate, frozen vial for each special coagulation assay ordered. Please submit two frozen vials of plasma and ship frozen samples on dry ice to laboratory.
Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Plasma must be free of platelets (<10,000/mcL). Freeze immediately and transport on dry ice.
General Drawing Instructions: Refer to Quest Diagnostics Nichols Institute Directory of Services under Specimen Collection section, Coagulation Testing, for further information on specimen processing.
Transport Container
Plastic screw-cap vial
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis
Methodology
See individual tests
Setup Schedule
Set up: Tues-Sat; Report available: Next day
Limitations
Protein S, Activity: Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: decrease; Heparin (UFH or LMWH): may falsely increase at values approximately greater than 1.0 IU/mL; Dabigatran or Argatroban (Thrombin Inhibitors): may falsely increase; Rivaroxaban or Apixaban (Factor Xa Inhibitors): may falsely increase.
Protein S Antigen, Total: Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: no effect to decrease; Heparin (UFH or LMWH): no effect; Dabigatran or Argatroban (Thrombin Inhibitors): no effect; Rivaroxaban or Apixaban (Factor Xa Inhibitors): no effect.
Reference Range
Protein S Antigen | 70-140 % normal |
Protein S Activity | |
Male | 70-150 % normal |
Female | 60-140 % normal |
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153