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Herpes Simplex (HSV) and Varicella-Zoster Virus (VZV) Direct Iummunofluorescence
Test Code18852
CPT Codes
87290, 87299
Preferred Specimen
3 mL swab collection from vesicular, oral, genital (external), or skin lesions submitted in VCM Transport Medium
Minimum Volume
1 mL
Other Acceptable Specimens
Swab collection from vesicular, oral, genital (external), or skin lesions submitted in UTM or M4 Transport Medium
Instructions
Oral includes: Lips, Mouth, Gums, Palate and Throat
Genital that includes: Labia, Vulva, Vagina, Perineum, Penile, and Anal
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 72 hours
Frozen (-70°C): 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Dry swabs • Non-gel based bacterial transport • Formalin or other fixatives • Gel-based transport system • Nucleic acid transport systems • Calcium alginate swabs • Wooden swabs
Methodology
Direct Immunofluorescence Assay (DFA)
Setup Schedule
Set up: Mon-Fri p.m.; Report available: Next day
Reference Range
Negative
Clinical Significance
The DFA test methodology provides a rapid diagnostic procedure for the detection of HSV and VZV. This type of lab results, in conjunction with all the other information about the patient, can assist the physician in rendering a diagnosis. The rapid diagnosis of viral infections facilitates the appropriate selection of antiviral drug therapy.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153