17-Hydroxypregnenolone, LC/MS/MS [8352X]

Test Code
34972

CPT Codes
84143

Preferred Specimen
2 mL serum collected in a red-top tube (no gel)

Minimum Volume
0.4 mL

Transport Container
Plastic screw-cap vial

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 24 hours
Refrigerated: 5 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST®)

Methodology
Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS)

Limitations
Infants with 21-hydroxylase deficiency may present with non-elevated results.

Reference Range
See Laboratory Report

Clinical Significance
17-Hydroxypregnenolone is useful in the diagnosis of 3-Beta-Hydroxylase enzyme deficiency, a rare cause of congenital adrenal hyperplasia, and 17-Hydroxylase (P450c17) enzyme deficiency.

Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92675



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.