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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
NT-proBNP
Test CodeLAB106
Alias/See Also
BNP
CPT Codes
83880
Preferred Specimen
Preferred: Light Green
Acceptable Gold and Red
Acceptable Gold and Red
Instructions
Centrifuge within 2 hours of collection.
Transport Temperature
Refrigerated
Specimen Stability
Ambient: 24 hours-on cells/gel, 48 hours if taken off cells/gel
Refrigerated: 3 days off cells/gel
Frozen: 30 days off cells/gel
Refrigerated: 3 days off cells/gel
Frozen: 30 days off cells/gel
Methodology
Chemiluminescent Immunoassay
Setup Schedule
Sunday-Saturday
Reference Range
| NT-proBNP pediatric reference intervals are adapted from central 95% intervals in healthy children (ref 1). | < 1yr, no reference range established |
| 2-5 yrs, < 280 pg/mL | |
| 6-11 yrs, < 255 pg/mL | |
| 12-15 yrs, <165 pg/mL | |
| 16-18 yrs, male < 85 pg/mL, female < 150 pg/mL | |
| NT-proBNP adult reference intervals are adapted from the cutoffs used to rule out HF in patients with acute dyspnea (ref 2). | >= 18 yrs, < 300 pg/mL |
| hsTnI pediatric reference intervals are adapted from central 95% intervals in healthy children (ref 3). | < 1yr, no reference range established |
| 1-7 yrs, <9 ng/L | |
| 8-12 yrs, <14 ng/L | |
| 13-18 yrs, < 17 ng/L |
Clinical Significance
NT-proBNP result comment:
Heart failure (HF) is a clinical diagnosis based upon patient history and physical examination in conjunction with laboratory tests and imaging procedures. The following cutoffs were suggested to evaluate HF in patients with acute dyspnea.
Negative (heart failure unlikely): adults (>=18 yrs), <300 pg/mL
Positive (heart failure likely):
18 - 49 yrs >=450 pg/mL
50 - 75 yrs >=900 pg/mL
>75 yrs >=1800 pg/mL
Grayzone (heart failure is possible): all other intermediate levels. Consider other causes of NT-proBNP elevation.
To screen asymptomatic adults with diabetes for the development of cardiac structural or functional abnormalities, American Diabetes Association recommends using the cutoff >125 pg/mL.
NT-proBNP concentrations may be elevated due to impaired renal function (eGFR < 60 mL/min/1.73 m2), history of heart failure, acute coronary syndrome, atrial fibrillation, other cardiac diseases or pulmonary diseases, and sepsis. NT-proBNP concentrations may be decreased due to obesity (BMI >= 30 kg/m2), flash pulmonary edema, pericarditis, cardiac tamponade and other conditions.
Heart failure (HF) is a clinical diagnosis based upon patient history and physical examination in conjunction with laboratory tests and imaging procedures. The following cutoffs were suggested to evaluate HF in patients with acute dyspnea.
Negative (heart failure unlikely): adults (>=18 yrs), <300 pg/mL
Positive (heart failure likely):
18 - 49 yrs >=450 pg/mL
50 - 75 yrs >=900 pg/mL
>75 yrs >=1800 pg/mL
Grayzone (heart failure is possible): all other intermediate levels. Consider other causes of NT-proBNP elevation.
To screen asymptomatic adults with diabetes for the development of cardiac structural or functional abnormalities, American Diabetes Association recommends using the cutoff >125 pg/mL.
NT-proBNP concentrations may be elevated due to impaired renal function (eGFR < 60 mL/min/1.73 m2), history of heart failure, acute coronary syndrome, atrial fibrillation, other cardiac diseases or pulmonary diseases, and sepsis. NT-proBNP concentrations may be decreased due to obesity (BMI >= 30 kg/m2), flash pulmonary edema, pericarditis, cardiac tamponade and other conditions.
Performing Laboratory
West Virginia University Hospital, Inc.
Berkeley Medical Center
Braxton County Memorial Hospital
Camden Clark Medical Center
Fairmont Medical Center
Jefferson Medical Center
Reynolds Memorial Hospital
Summersville Regional Medical Center
St Joseph's Hospital
United Hospital Center
