Metanephrines, Fractionated, LCMSMS, Random Urine [14961X]

Test Code

MFRU

CPT Codes
82570, 83835

Includes

Metanephrines, Normetanephrines, Total Metanephrines, Creatinine

Preferred Specimen

5 mL random urine with 6N HCl or Unpreserved random urine

Patient Preparation
It is preferable for the patient to be off medications for three days prior to collection. Patient should avoid tobacco, tea, coffee, for three days prior to specimen collection. Common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Medications which are alpha agonists (Aldomet), alpha blockers (Dibenzyline) should be avoided 18-24 hours prior to specimen collection.

Minimum Volume

1.5 mL

Other Acceptable Specimens

Unpreserved random urine

Instructions

After urine collection, add 6N HCl to maintain a pH below 3. Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen. Record patients age on test request form and urine vial.

Transport Temperature

Preserved urine: Room temperature

Unpreserved urine: Frozen

Specimen Stability

Room temperature: 7 days Refrigerated: 8 days Frozen: 30
days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Urine collected with boric acid

Methodology

Kinetic Alkaline Picrate • Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon-Sat; Report available: 2 days

Reference Range

See Laboratory Report

Clinical Significance

Useful in the evaluation of pheochromocytoma.

Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153

Last Updated: February 20, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.