Beta-Globin Complete

Message

Whole blood: Normal phlebotomy procedure. Specimen stability is
crucial. Store and ship ambient immediately. Do not
freeze.

Extracted DNA is not an acceptable
specimen type.

Chorionic villi samples are no longer acceptable.

Test Code

BGCOM

Alias/See Also

LAB11270

Thalassemia

Beta-Thalassemia Mutation Analysis

CPT Codes
81364

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Preferred Specimen

5 mL whole blood

Minimum Volume

3 mL

Other Acceptable Specimens

Whole blood collected in: sodium heparin (green-top) tube

Instructions

Whole blood: Normal phlebotomy procedure. Specimen stability is crucial. Store and ship ambient immediately. Glass tubes should not be shipped frozen.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 8 days Refrigerated: 8 days Frozen:
Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received frozen

Methodology
DNA Sequencing • Polymerase Chain Reaction (PCR)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Mon, Thurs a.m.

Report Available

16 days

Limitations

If these mutations are not found by the testing procedure, it does not mean that the risk of carrying or developing beta thalassemia is not present. It simply means that these specific mutations have not seen found with this assay, although other mutations may be present.

Reference Range

See Laboratory Report

Clinical Significance

1) To identify disease-causing mutations in individuals affected with beta-thalassemia.
2) To identify carriers in high-risk ethnic group or people with positive family history.
3) Prenatal diagnosis of beta-thalassemia.

Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano 33608 Ortega Highway San Juan Capistrano, CA 92675

Last Updated: February 17, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.