Ashkenazi Jewish Panel (4 Tests)

Message

CF Method: PCR and Allelic
discrimination using an oligonucleotide-ligation (OLA) assay.

Whole blood: Normal phlebotomy procedure. Specimen stability is
crucial. Store and ship at room temperature immediately. Do not
freeze.

Test Code

ASHJ

Alias/See Also

LAB2938

CPT Codes
81200, 81220, 81255, 81260

Includes

Cystic Fibrosis, Tay-Sachs DNA, Canavan Disease, Familial Dysautonomia

Preferred Specimen

5 mL Whole blood collected in: EDTA
(royal blue-top), or ACD solution A or B
(yellow-top), or sodium or lithium heparin (green-top) tube

Minimum Volume

3mL

Other Acceptable Specimens

Whole blood collected in: EDTA (royal blue-top), or ACD solution A or B (yellow-top), or sodium or lithium heparin (green-top) tube

Instructions

CF Method: PCR and Allelic discrimination using an oligonucleotide-ligation (OLA) assay.

Whole blood: Normal phlebotomy procedure. Specimen stability is crucial. Store and ship at room temperature immediately. Do not freeze.

Transport Temperature

Room Temperature

Specimen Stability

Room temperature: 8 days Refrigerated: 8 days Frozen:
Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

N/A

Methodology

Multiplex PCR • Massively Parallel Sequencing (MPS) • Allele-Specific Primer Extension Fluorescent Detection Using Color Coded Microspheres • Polymerase Chain Reaction (PCR)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Daily AM

Report Available

7 days

Reference Range

See Laboratory Report

Clinical Significance

This panel consists of the diseases frequent in the Ashkenazi Jewish population that have been recommended for population based carrier screening by the Americal College of Obstetricians and Gynecologists (ACOG) and the American College of Medical Genetics. This panel screens for Cystic Fibrosis, Tay-Sachs (DNA), Canavan Disease, and Familial Dysautonomia.

Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano 33608 Ortega Highway San Juan Capistrano, CA 92675

Last Updated: February 17, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.