17-Hydroxypregnenolone, LC/MS/MS

Test Code

17HDP

Alias/See Also

LAB530

CPT Codes
84143

Preferred Specimen

2 mL serum

Minimum Volume

0.4 mL

Transport Temperature

Refrigerated

Specimen Stability

Room temperature: 24 hours Refrigerated: 5 days Frozen: 28
days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Serum Separator tube (SST)

Methodology

Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Sun – Fri nights

Report Available

3 – 6 days

Limitations

Infants with 21-hydroxylase deficiency may present with non-elevated results.

Reference Range

See Laboratory Report

Clinical Significance

17-Hydroxypregnenolone is useful in the diagnosis of 3-Beta-Hydroxylase enzyme deficiency, a rare cause of congenital adrenal hyperplasia, and 17-Hydroxylase (P450c17) enzyme deficiency.

Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano 33608 Ortega Highway San Juan Capistrano, CA 92675

Last Updated: February 17, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.