A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Topiramate

Test Code
TOPAM


Alias/See Also

LAB498



CPT Codes
<p>80201</p>

Preferred Specimen

Specimen Type: Serum

Collection Container/Type

Preferred: Red top

Acceptable: Plain, royal blue-top Vacutainer plastic trace element blood collection tube

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: 

  1. Draw at peak (2-4 hours after dose) or trough (0.5-1 hour before dose) at steady-state.

 

Specimen Type: Plasma

Collection Container/Type

Preferred: Green top (lithium heparin)

Acceptable: Green top (sodium heparin)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: 

  1. Draw at peak (2-4 hours after dose) or trough (0.5-1 hour before dose) at steady-state.


Minimum Volume

0.5 mL



Other Acceptable Specimens
Plasma collected in a sodium heparin (green-top), or sodium heparin lead-free (tan-top) tube


Instructions
Draw at peak (2-4 hours after dose) or trough (0.5-1 hour before dose) at steady-state.


Transport Temperature
Room temperature


Specimen Stability

Room temperature: 7 days


Refrigerated: 14 days


Frozen: 30 days



Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gel barrier/serum separator tube



Methodology

Chromatography/Mass Spectrometry

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.



FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Mon-Sat a.m.; Report available: 2 days


Report Available

2 days



Reference Range
Therapeutic Range
Dose (mg) Peak (mcg/mL) Trough (mcg/mL)
100 6.5-9.2 4.5-6.6
200 12.0-16.0 8.0-12.0
400 20.0-30.0 14.0-20.0


Clinical Significance
Topiramate is an anticonvulsant used as an adjunctive treatment of partial-onset epilepsy. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.


Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153


Last Updated: February 17, 2023


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.