A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Cryoglobulin (% Cryocrit), Serum

Test Code
CRYOQ


Alias/See Also

LAB713



CPT Codes
<p>82595</p>

Preferred Specimen

Patient Preparation: Overnight fasting is required.


Specimen Type: Serum Red


Collection Container/Type: Red top


Submission Container/Tube: Plastic vial


Specimen Volume: 6 mL 


Collection Instructions: 



  1. Allow serum sample to clot for one (1) hour in a 37° C water bath, oven, incubator, or heat block.

  2. After clotting, centrifuge the specimen for 10 minutes at 1600 RCF(G) utilizing one of the 3 options below:

    1. In a "warm" centrifuge at 37° C.

    2. In a bench-top centrifuge placed in a "warm room" at 37° C.

    3. At room temperature, in a bench-top centrifuge prewarmed by running it for 10 minutes at 1600 RCF(G).



  3. After centrifuging, decant serum into a screw-cap vial and transport at room temperature.


Additional Information:



  • If the sample is NOT kept at 37° C during all processing steps, the cryoprecipitate if present can precipitate out of solution and be lost in the clot or during the centrifugation process and result in a false negative result.

  • DO NOT REFRIGERATE OR FREEZE.

  • No tests can be added or poured off this tube; cryocrit and cryoglobulin evaluation only.

     



Minimum Volume

3 mL



Instructions
Allow blood to clot for one (1) hour in a 37° C water bath, incubator, heat block or heel warmer. After clotting, centrifuge the specimen as quickly as possible. It is not necessary to use a warm centrifuge but do not use a refrigerated one. Decant all of the serum into one transport vial (do not aliquot any of the cryoglobulin serum into any other tube). Transport at room temperature preferred.

Note: If the sample is not kept at 37° C during clotting, the cryoglobulin, if present, can precipitate during centrifugation and be lost in the clot resulting in a false negative result.


Transport Temperature
Room temperature


Specimen Stability

Room temperature: 72 hours


Refrigerated: Unacceptable


Frozen: Unacceptable



Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic • Icteric • Serum separator tube (SST)



Methodology

Visual Inspection



Setup Schedule
Set up: Daily; Report available: 5-7 days


Report Available

5-7 days



Reference Range
Cryoglobulin Qualitative Negative
% Cryocrit None detected


Clinical Significance
The cryocrit is primarily intended for following a patient with previously defined and quantitated cryoglobulins. The cryocrit may consist of cryoglobulins, fibrins or mixtures of cryoglobulins and fibrins. If not previously characterized, consider ordering Cryoglobulin Screen with Reflex to Cryoglobulin Profile, Serum.


Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153


Last Updated: February 17, 2023


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.