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Calreticulin (CALR) Mutation Analysis
Test CodeAlias/See Also
LAB12701
CPT Codes
<p>81219</p>
Preferred Specimen
Submit only 1 of the following specimens:
Specimen Type: Whole blood
Collection Container/Type: Lavender top (EDTA) or yellow top (ACD solution B)
Specimen Volume: 4 mL
Collection Instructions:
1. Invert several times to mix blood.
2. Send whole blood specimen in original tube. Do not aliquot.
3. Label specimen as blood.
Additional Information: Do not reject specimens, send to laboratory for screening.
Specimen Type: Bone marrow
Collection Container/Type: Lavender top (EDTA) or yellow top (ACD solution B)
Specimen Volume: 3 mL
Collection Instructions:
-
nvert several times to mix bone marrow.
-
Send bone marrow specimen in original tube. Do not aliquot.
-
Label specimen as bone marrow.
Additional Information: Do not reject specimens, send to laboratory for screening.
Specimen Type: Extracted DNA from blood or bone marrow
Collection Container/Type: 1.5- to 2-mL tube
Specimen Volume: Entire specimen
Collection Instructions: Label specimen as extracted DNA from blood or bone marrow and include indication of volume and concentration of the DNA.
Additional Information: Do not reject specimens, send to laboratory for screening.
Minimum Volume
Whole blood: 3 mL
Bone marrow: 1 mL
Other Acceptable Specimens
Instructions
Cell Pellets: Send fixed samples within 7 days of fixation date in a plastic, leak-proof tube/container. Indicate type of fixative used along with patient name, specimen source, date collected, and date harvested/fixed. Cell pellets submitted in Carnoy's or other alcohol-based fixatives are acceptable.
Transport Temperature
Specimen Stability
Whole blood, bone marrow aspirate
Room temperature: 7 days
Refrigerated: 7 days
Frozen: Unacceptable
Extracted DNA
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 1 year
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Do not reject specimens, send to laboratory for screening.
Methodology
Polymerase Chain Reaction-based DNA Sequencing
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Report Available
5-7 days
Reference Range
Clinical Significance
Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153
Last Updated: February 17, 2023