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Lithium
Test CodeLITHM
Alias/See Also
Epic: LAB29
Preferred Specimen
Specimen Type: Serum
Collection Container: Serum gel
Specimen Volume: 3 mL
Minimum Volume
3.5 mL
Other Acceptable Specimens
Collection Container: Red top
Instructions
- Draw trough sample 12 hours after last dose.
- Centrifuge and separate cells after clot formation and within 4 hours of collection.
- Peak concentration is reached 2 to 4 hours after oral dose.
Transport Container
Plastic vial
Specimen Stability
Room temperature: 1 day
Refrigerated: 7 days
Frozen: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Unlabeled, mislabeled, wrong tube type, PLASMA, QNS, hemolyzed
Methodology
Colorimetric
Setup Schedule
Daily
Report Available
Same day
Reference Range
1.0 - 1.2 mEg/L
Clinical Significance
Lithium is used in the treatment of manic depressive psychosis. It acts on the neurotransmitters and produces a sedative effect on the CNS. Because lithium has a narrow therapeutic range, it should be monitored closely for toxicity. Elevated levels can cause toxicity. Early symptoms of toxicity include apathy, sluggishness, drowsiness, lethargy, speech difficulties, tremor, muscle weakness, and ataxia.
Long-term lithium therapy has been reported to cause hyperparathyroidism in some individuals, with resulting hypercalcemia.
Long-term lithium therapy has been reported to cause hyperparathyroidism in some individuals, with resulting hypercalcemia.
Performing Laboratory
Inova Laboratories
2832 Juniper Street
Fairfax, VA 22031
Last Updated: April 11, 2023
Last Review: N. Wolford, April 11, 2023