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Immunoglobulin G (IgG)
Test CodeAlias/See Also
Preferred Specimen
Specimen Type: Serum
Collection Container: Serum gel
Specimen Volume: 3 mL
Minimum Volume
0.25 mL
Other Acceptable Specimens
Collection Container: Red top
Instructions
Transport Container
Specimen Stability
Room temperature: 4 months
Refrigerated: 8 months
Frozen: 8 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
nlabeled, mislabeled, wrong tube type, visually lipemic, QNS, exceeds specimen stability requirements.
Methodology
Immunoturbidimetric
Setup Schedule
Daily
Report Available
Same day
Limitations
Samples containing paraproteins (abnormal monoclonal antibodies) may incorrectly fall within the reference range. Samples with elevated total protein concentrations or suspected paraproteinemia can be screened with other methods such as electrophoresis. Turbidity and particles in samples can interfere with the assay. Therefore, particulate matter should be removed by centrifugation prior to running the assay.
Reference Range
1 month - 1 year: 203 - 948 mg/dL
1 - 2 years: 475 - 1226 mg/dL
2 - 150 yers: 540 - 1822 mg/dL
Clinical Significance
Elevated polyclonal IgG levels are associated with autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, and Sjogren’s syndrome), chronic liver disease, some parasitic diseases, chronic or recurrent infections, and intrauterine contraceptive devices. Increased oligoclonal IgG levels are associated with malignancies, infections (especially in the elderly), some dysgammaglobulinemias, and autoimmune disorders. Increased monoclonal IgG levels are associated with multiple myeloma (IgG type), lymphomas, and leukemia.
Performing Laboratory
Inova Laboratories
2832 Juniper Street
Fairfax, VA 22031
Last Updated: April 11, 2023
Last Review: N. Wolford, April 11, 2023