FK506

Test Code

FK506

Alias/See Also

Epic: LAB876

Prograf
Tacrolimus

Preferred Specimen

Specimen Type: Whole blood EDTA
Collection Container: Lavender top (EDTA)
Specimen Volume:3 mL

Minimum Volume

0.5 mL

Instructions

Do not centrifuge
Send whole blood specimen in original tube. Do not aliquot

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 7 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Unlabeled, mislabeled, wrong tube type, , clotted, QNS, exceeds specimen/stability requirements.

Methodology

Chemiluminescent microparticle immunoassay (CMIA)

Setup Schedule

Daily

Report Available

Same day

Reference Range

5.0 – 20.0 ng/mL

Clinical Significance

Tacrolimus (FK506, Prograf) is a calcineurin inhibitor that blocks activation of the transcription-regulating factor, preventing transcription of the gene coding for IL-2 and blunting T-cell activation. It is a widely used drug for bone marrow and organ transplantation, administered early after transplant and later for maintenance therapy. The goal for maintenance therapy is to achieve optimal immunosuppression while minimizing dose-dependent toxicity. Peak levels are reached 1-2 hours after oral dose. Maintenance therapeutic levels are often collected according to trough values desired by clinical protocol.

Performing Laboratory

Inova Laboratories

2832 Juniper Street

Fairfax, VA 22031

Last Updated: March 7, 2023
Last Review: N. Wolford, March 7, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.