Myeloperoxidase Antibody

Test Code

MPXAB

Alias/See Also

LAB3268

CPT Codes
86021

Preferred Specimen

1 mL serum

Minimum Volume

0.3 mL

Transport Container

Plastic screw-cap vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days Refrigerated: 14 days Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis

Methodology

Immunoassay (IA)

Setup Schedule

Set up: Tues-Sat a.m.; Report available: Next day

Limitations

Approximately 90% of patients with a P-ANCA pattern by IFA have myeloperoxidase-specific antibodies.

Reference Range

<1.0 AI	No antibody detected
≥1.0 AI	Antibody detected

Clinical Significance

Autoimmune vasculitis diseases are characterized by abnormal immune responses that result in inflammation and necrosis of blood vessels. The immune dysfunction may be triggered by infection, autoimmune disease, or exposure to a drug; often the cause is unknown. ANCA-associated vasculitis diseases are often characterized by the size of the blood vessels involved. The diseases present with diverse clinical features and are often rapidly progressive, causing irreversible injury to the vessels of the organs affected, such as the kidneys and lungs.

Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153

Last Updated: February 23, 2012

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.