Proteinase-3 Antibody

Specimen Type: Serum

Collection Container/Type

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: 

1. Centrifuge and separate cells after clot formation and within 4 hours of collection. 

0.3 mL

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Gross hemolysis

Tues-Sat a.m.

Next day

Autoimmune vasculitis diseases are characterized by abnormal immune responses that result in inflammation and necrosis of blood vessels. The immune dysfunction may be triggered by infection, autoimmune disease, or exposure to a drug; often the cause is unknown. ANCA-associated vasculitis diseases are often characterized by the size of the blood vessels involved. The diseases present with diverse clinical features and are often rapidly progressive, causing irreversible injury to the vessels of the organs affected, such as the kidneys and lungs.

Goodpasture's Syndrome, first described by Ernest Goodpasture in 1919, is characterized today by the triad of diffuse lung hemorrhage, proliferative nephritis and the presence of anti-GBM autoantibodies, which are present as linear deposits along the glomerular and alveolar basement membranes, and as circulating antibodies.