Neuromyelitis Optica Antibody

Message

Sendout, Mayo test code: NMOFS

Test Code

LAB5210714

Alias/See Also

NMO
AQP
Devic's Antibody
Optix Neuritix Ab
Optic-spincal MS Ab
Soft-NMOS
Transverse Myelitis Ab
Vision Loss Ab
Aquaporin-2 Receptor Antibody
Aquaporin-4 Receptor Antibody
NMOFS

CPT Codes
86255

Includes

When the results of this assay require further evaluation, NMOTS / Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Titer Assay, Serum will be performed at an additional charge.

Preferred Specimen

3 mL serum from a red tube

Minimum Volume

2 mL

Other Acceptable Specimens

Serum gel tube

Instructions

Centrifuge and aliquot serum into a plastic vial.

Transport Container

Plastic vial

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated (preferred): 28 days
Frozen: 28 days
Ambient: 72 hours

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Methodology
Flow Cytometry

FDA Status
Approved

Setup Schedule

Monday, Tuesday, Thursday

Report Available

5-8 days

Limitations

AQP4-IgG antibodies may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).

Reference Range

Included with report

Clinical Significance

Diagnosis of a neuromyelitis optica spectrum disorder (NMOSD)

Diagnosis of autoimmune AQP4 channelopathy

Diagnosis of neuromyelitis optica (NMO)

Distinguishing NMOSD from multiple sclerosis early in the course of disease

Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota

Additional Information
Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Assay, Serum

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.