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Cystatin C with Estimated GFR
MessageSendout, Mayo test code: CSTCE
Test Code
LAB5210180
Alias/See Also
Cystatin C with eGFR
CSTCE
CSTCE
CPT Codes
82610
Preferred Specimen
1 mL serum from a gold serum gel tube
Minimum Volume
0.25 mL
Other Acceptable Specimens
Red tube
Instructions
1. Serum gel tubes should be centrifuged within 2 hours of collection.
2. Red-top tubes should be centrifuged and serum aliquoted into a plastic vial within 2 hours of collection.
2. Red-top tubes should be centrifuged and serum aliquoted into a plastic vial within 2 hours of collection.
Transport Container
Plastic vial
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated (preferred): 14 days
Frozen: 30 days
Ambient: 7 days
Frozen: 30 days
Ambient: 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis: Reject
Gross lipemia: OK
Gross icterus: Reject
Gross lipemia: OK
Gross icterus: Reject
Methodology
Immunoturbidimetric
FDA Status
Approved
Setup Schedule
Monday through Sunday
Report Available
1-3 days
Limitations
Cystatin C:
Cystatin C inversely correlates with the glomerular filtration rate (GFR), that is, elevated levels of cystatin C indicate decreased GFR. Cystatin C may provide more accurate assessment of GFR for very obese, older adults, or malnourished patients than creatinine. Cystatin C equation does not require patient ethnic data and can be used for those patients with this information unavailable.
Due to immaturity of kidney function, cystatin C levels are higher in neonates less than 3 months of age.(3)
Estimated GFR:
Chronic kidney disease (CKD) is defined as the presence of persistent and usually progressive reduction in GFR (GFR <60 mL/min/1.73 m[2]) and/or albuminuria (>30 mg of urinary albumin per gram of urinary creatinine), regardless of GFR.
Cystatin C inversely correlates with the glomerular filtration rate (GFR), that is, elevated levels of cystatin C indicate decreased GFR. Cystatin C may provide more accurate assessment of GFR for very obese, older adults, or malnourished patients than creatinine. Cystatin C equation does not require patient ethnic data and can be used for those patients with this information unavailable.
Due to immaturity of kidney function, cystatin C levels are higher in neonates less than 3 months of age.(3)
Estimated GFR:
Chronic kidney disease (CKD) is defined as the presence of persistent and usually progressive reduction in GFR (GFR <60 mL/min/1.73 m[2]) and/or albuminuria (>30 mg of urinary albumin per gram of urinary creatinine), regardless of GFR.
Reference Range
Included with report
Clinical Significance
Assessing kidney function in patients suspected of having kidney disease
Monitoring treatment response in patients with kidney disease
An index of glomerular filtration rate (GFR), especially in patients where serum creatinine may be misleading (eg, very obese, older adults, or malnourished patients)
Calculation of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) cystatin C estimated GFR for patients where serum creatinine may be misleading (eg, very obese, older adults, or malnourished patients)
Monitoring treatment response in patients with kidney disease
An index of glomerular filtration rate (GFR), especially in patients where serum creatinine may be misleading (eg, very obese, older adults, or malnourished patients)
Calculation of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) cystatin C estimated GFR for patients where serum creatinine may be misleading (eg, very obese, older adults, or malnourished patients)
Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota
Additional Information
Cystatin C with Estimated Glomerular Filtration Rate (eGFR), Serum
