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PSA, Ultrasensitive
MessageSendout, Mayo test code: PSAU
Test Code
LAB578
Alias/See Also
Prostate Specific Antigen (PSA) Ultrasensitive
Post Prostatectomy
PSA, Third Generation
Ultrasensitive PSA
PSAU
Post Prostatectomy
PSA, Third Generation
Ultrasensitive PSA
PSAU
CPT Codes
84153
Preferred Specimen
1 mL serum from a gold serum gel tube
Minimum Volume
0.75 mL
Other Acceptable Specimens
Red tube
Instructions
1. Serum gel tubes should be centrifuged within 2 hours of collection.
2. Red-top tubes should be centrifuged, and the serum aliquoted into a plastic vial within 2 hours of collection.
2. Red-top tubes should be centrifuged, and the serum aliquoted into a plastic vial within 2 hours of collection.
Transport Temperature
Frozen
Specimen Stability
Frozen (preferred): 180 days
Refrigerated: 14 days
Ambient: 7 days
Refrigerated: 14 days
Ambient: 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Methodology
Electrochemiluminescent Immunoassay (ECLIA)
Setup Schedule
Monday through Saturday
Report Available
1-3 days
Limitations
Serum markers are not specific for malignancy, and values may vary by method.
When age is not supplied, the results cannot be flagged as high or low.
Digital rectal examination generally does not increase normal prostate-specific antigen (PSA) values. However, cystoscopy, urethral instrumentation, and prostate biopsy may increase PSA levels.
In rare cases, some individuals can develop antibodies to mouse or other animal antibodies (often referred to as human anti-mouse antibodies [HAMA] or heterophile antibodies), which may cause interference in some immunoassays. The presence of antibodies to streptavidin or ruthenium can also rarely occur and may interfere in this assay. Caution should be used in interpretation of results, and the laboratory should be alerted if the result does not correlate with the clinical presentation.
No interference was observed from rheumatoid factors up to a concentration of 1500 IU/mL.
There is no high-dose hook effect at total PSA concentrations up to 17,000 ng/mL.
Serum biotin concentrations up to 1200 ng/mL do not interfere with this assay. Concentrations up to 1200 ng/mL may be present in specimens collected from patients taking extremely high doses of biotin up to 300 mg per day.(2) In a study among 54 healthy volunteers, supplementation with 20 mg/day biotin resulted in a maximum serum biotin concentration of 355 ng/mL 1 hour post-dose.(3)
When age is not supplied, the results cannot be flagged as high or low.
Digital rectal examination generally does not increase normal prostate-specific antigen (PSA) values. However, cystoscopy, urethral instrumentation, and prostate biopsy may increase PSA levels.
In rare cases, some individuals can develop antibodies to mouse or other animal antibodies (often referred to as human anti-mouse antibodies [HAMA] or heterophile antibodies), which may cause interference in some immunoassays. The presence of antibodies to streptavidin or ruthenium can also rarely occur and may interfere in this assay. Caution should be used in interpretation of results, and the laboratory should be alerted if the result does not correlate with the clinical presentation.
No interference was observed from rheumatoid factors up to a concentration of 1500 IU/mL.
There is no high-dose hook effect at total PSA concentrations up to 17,000 ng/mL.
Serum biotin concentrations up to 1200 ng/mL do not interfere with this assay. Concentrations up to 1200 ng/mL may be present in specimens collected from patients taking extremely high doses of biotin up to 300 mg per day.(2) In a study among 54 healthy volunteers, supplementation with 20 mg/day biotin resulted in a maximum serum biotin concentration of 355 ng/mL 1 hour post-dose.(3)
Reference Range
Included with report
Clinical Significance
Monitoring disease after radical prostatectomy
This test should not be used for initial prostate cancer screening.
This test should not be used for initial prostate cancer screening.
Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota
Additional Information
Prostate-Specific Antigen (PSA) Ultrasensitive, Serum
