Haptoglobin

Message

Chemistry

Test Code

LAB89

CPT Codes
83010

Preferred Specimen

Gold top (serum separator tube)

Minimum Volume

Whole blood: 600 uL (TWO full red-top microtainers or one full light green-top microtainer).

Serum/plasma: 300 uL

Other Acceptable Specimens

Red Top and light green top (lithium heparin plasma) acceptable

Specimen Stability

Room Temperature: 1 day
Refrigerated: 4 days
Frozen: Not recommended

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolyzed specimens

Setup Schedule

Monday-Sunday

Reference Range

All Ages: 30-200 mg/dL

Clinical Significance

Haptoglobin is a plasma glycoprotein synthesized predominately by the liver. It consists of at least two heavy chains and two light chains covalently attached via disulfide linkage. Heterogeneity in molecular mass and structure is due to genetic polymorphism of the light chain where three major haptoglobin phenotypes are observed. A major role of haptoglobin is binding of hemoglobin in the bloodstream. Haptoglobin-hemoglobin complexes are transported to the liver or catabolic processing and preventing iron loss. The ability and capacity of haptoglobin to bind hemoglobin allows its use as an indication of intravascular hemolysis where levels are reduced or depleted. Haptoglobin is also an acute-phase protein where levels can exceed three times that of normal during an inflammatory response.

Performing Laboratory
Hoag Newport Lab

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.