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Alpha-1-Antitrypsin, Serum

Message
Sendout, Mayo test code: AAT


Test Code
LAB810


Alias/See Also
Alpha 1 Antitrypsin Anti-Alpha-1-Trypsin Prolastin A1A AAT (Alpha-1-Antitrypsin) Alpha-1-Antitrypsin Reflex AAT


CPT Codes
82103

Preferred Specimen
1 ml of serum from a red tube.


Minimum Volume
0.5 mL


Other Acceptable Specimens
Serum gel tube


Transport Temperature
Refrigerate


Specimen Stability
Room temperature: 28 days 
Refrigerated (preferred): 28 days 
Frozen: 28 days 


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, lipemia or icterus.


Methodology
Nephelometry

FDA Status
Approved

Setup Schedule
Monday through Friday


Report Available
1-2 days


Limitations
Low alpha-1-antitrypsin (A1A) levels may result from liver disease, and A1A proteotype testing should be done to confirm A1A deficiency disease.
 
A1A is an acute-phase reactant, and any inflammatory process will elevate serum A1A levels.
 
Quantitation of specific proteins by nephelometric means may not be possible in lipemic sera due to the extreme light scattering properties of the specimen. Turbidity and particles in the specimen may result in extraneous light scattering signals, resulting in variable specimen analysis.


Reference Range
Included with report


Clinical Significance
Workup of individuals with suspected disorders such as familial chronic obstructive lung disease.
 
Diagnosing alpha-1-antitrypsin deficiency.


Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota

Additional Information
Alpha-1-Antitrypsin, Serum


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.