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Salivary Cortisol
MessageSendout, Mayo test code: SALCT
Test Code
LAB10005
Alias/See Also
Nighttime Salivary Cortisol
Salivary Cortisol
Salivary Cushings
Salivary Hydrocortisone
SALCT
Salivary Cortisol
Salivary Cushings
Salivary Hydrocortisone
SALCT
CPT Codes
82533
Preferred Specimen
1 mL collected in Cortisol, Saliva Collection Kit provided by laboratory.
Minimum Volume
0.6 mL
Instructions
1. Do not brush teeth before collecting specimen.
2. Do not eat or drink for 15 minutes prior to specimen collection.
3. Reference values are also available for an 8 a.m. (7 a.m.-9 a.m.) or a 4 p.m. (3 p.m.-5 p.m.) collection, however, the 11 p.m. to midnight collection is preferred.
4. If multiple specimens are collected, submit each vial under a separate order.
2. Do not eat or drink for 15 minutes prior to specimen collection.
3. Reference values are also available for an 8 a.m. (7 a.m.-9 a.m.) or a 4 p.m. (3 p.m.-5 p.m.) collection, however, the 11 p.m. to midnight collection is preferred.
4. If multiple specimens are collected, submit each vial under a separate order.
Transport Container
SARSTEDT Salivette
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated (preferred): 7 days
Frozen: 60 days
Ambient: 7 days
Frozen: 60 days
Ambient: 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Methodology
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
FDA Status
Approved
Setup Schedule
Monday, Wednesday, Friday
Report Available
2-4 days
Limitations
Acute stress (including hospitalization and surgery), alcoholism, depression, and many drugs (eg, exogenous glucocorticoids, anticonvulsants) can obliterate normal diurnal variation, affect response to suppression/stimulation tests, and cause elevated cortisol levels.
Cortisol levels may be increased in pregnancy and with exogenous estrogens.
Midnight salivary cortisol assay cannot diagnose hypocortisolism or Addison disease because of the limited sensitivity of the assay method.
Cortisol levels may be increased in pregnancy and with exogenous estrogens.
Midnight salivary cortisol assay cannot diagnose hypocortisolism or Addison disease because of the limited sensitivity of the assay method.
Reference Range
Included with report
Clinical Significance
Screening for Cushing syndrome.
Diagnosis of Cushing syndrome in patients presenting with symptoms or signs suggestive of the disease.
Diagnosis of Cushing syndrome in patients presenting with symptoms or signs suggestive of the disease.
Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota
Additional Information
Cortisol, Saliva
