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Acetylcholine Receptor Binding Antibody
MessageSendout, Mayo test code: ARBI
Test Code
LAB836
Alias/See Also
Acetylcholine Receptor (Muscle AChR) Antibodies
AChR (Acetylcholine Receptor)
Anti -Neuromuscular Junction Receptor Antibodies
Myasthenia Gravis Antibodies
ARBI
AChR (Acetylcholine Receptor)
Anti -Neuromuscular Junction Receptor Antibodies
Myasthenia Gravis Antibodies
ARBI
CPT Codes
83519
Preferred Specimen
1.5 mL serum from a red tube.
Patient Preparation
For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication.
Minimum Volume
1 mL
Other Acceptable Specimens
Gold serum separator tube
Transport Temperature
Refrigerated
Specimen Stability
Room temperature: 72 hours
Refrigerated (preferred): 28 days
Frozen: 28 days
Refrigerated (preferred): 28 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Grossly lipemic
Microbially contaminated
Grossly lipemic
Microbially contaminated
Methodology
Radioimmunoassay (RIA)
FDA Status
Approved
Setup Schedule
Monday through Sunday
Report Available
3-6 days
Limitations
The presence of elevated immunoglobulins due to therapeutic intervention or other disorders (ie, hypergammaglobulinemia) may lead to false-positive results.
Positive results may be found in some patients with Lambert-Eaton syndrome, paraneoplastic central nervous system, and peripheral nervous system autoimmune disorders and in healthy individuals.
The presence of alpha-bungarotoxin antibodies may interfere with this assay.
Specimens ideally should be collected prior to initiation of immunosuppressive therapies as these may reduce the sensitivity of this test.
Positive results may be found in some patients with Lambert-Eaton syndrome, paraneoplastic central nervous system, and peripheral nervous system autoimmune disorders and in healthy individuals.
The presence of alpha-bungarotoxin antibodies may interfere with this assay.
Specimens ideally should be collected prior to initiation of immunosuppressive therapies as these may reduce the sensitivity of this test.
Reference Range
Included with report
Clinical Significance
Supporting the diagnosis of autoimmune myasthenia gravis (MG) in adults and children.
Distinguishing autoimmune from congenital MG in adults and children or other acquired forms of neuromuscular junction transmission disorders.
An adjunct to the test for P/Q-type calcium channel binding antibodies as a diagnostic aid for Lambert-Eaton myasthenic syndrome.
Distinguishing autoimmune from congenital MG in adults and children or other acquired forms of neuromuscular junction transmission disorders.
An adjunct to the test for P/Q-type calcium channel binding antibodies as a diagnostic aid for Lambert-Eaton myasthenic syndrome.
Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota
Additional Information
Acetylcholine Receptor (Muscle AChR) Binding Antibody, Serum
