Methylmalonic Acid, Serum

Message

Sendout, Mayo test code: MMAS

Test Code

LAB835

Alias/See Also

B12 Deficiency
CblC
Cobalamin Deficiency
Methylmalonate
Methylmalonic Acid (MMA)
MMA (Methylmalonic Acid)
Methylmalonic Aciduria
MMAS

CPT Codes
83921

Preferred Specimen

1.5 mL serum from a red tube

Minimum Volume

0.5 mL

Other Acceptable Specimens

Serum gel tube

Instructions

Centrifuge and aliquot serum into a plastic vial.

Transport Container

Plastic vial

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated: 48 days
Frozen: 48 months
Room temperature: 48 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis: OK
Gross lipemia: OK
Gross icterus: OK

Methodology
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

FDA Status
Approved

Setup Schedule

Monday through Friday

Report Available

3-5 days

Limitations

Diet, nutritional status, and age should be considered in the evaluation of serum or urine methylmalonic acid level.

Reference Range

Included with report

Clinical Significance

Evaluating children with signs and symptoms of methylmalonic acidemia using serum specimens

Evaluating individuals with signs and symptoms associated with a variety of causes of vitamin B12 (cobalamin) deficiency

Performing Laboratory

Additional Information
Methylmalonic Acid, Quantitative, Serum

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.