Alpha-1-Antitrypsin Phenotype, Serum

Message

Sendout, Mayo test code: A1APP

Test Code

LAB5210350

Alias/See Also

A1A Phenotyping
a-1-Antitrypsin, Phenotype
AAT Phenotyping
Alpha 1 Antitrypsin
Anti-Alpha-1-Trypsin
Antitrypsin
Antitrypsin, Phenotype
Pi Typing (Alpha-1-Antitrypsin Phenotyping)
Protease Inhibitor Allo Typing
Alpha-1-Antitrypsin Reflex
AIAPP

CPT Codes
82103, 82104

Preferred Specimen

1.25 mL serum from a red tube.

Minimum Volume

0.5 mL

Other Acceptable Specimens

Gold serum separator tube

Instructions

Centrifuge and aliquot serum into a plastic vial.

Transport Temperature

Refrigerated

Specimen Stability

Room temperature: 28 hours
Refrigerated (preferred): 28 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis, lipemia or icterus.

Methodology
Isoelectirc focusing

FDA Status
Approved

Setup Schedule

Monday through Friday

Report Available

2-6 days

Limitations

This assay identifies the phenotype of the circulating alpha-1-antitrypsin (A1A) protein. If the patient is already on replacement therapy, the phenotype will detect patient and replacement protein.

If 2 bands are seen, such as an M band and a Z bands, it is reported as MZ (eg, heterozygous).

If 1 band is seen, such as the Z band and the quantitative level is consistent with a homozygote, the phenotype is assumed to be homozygous and is reported as ZZ.

Reference Range

Included with report

Clinical Significance

Identification of homozygous and heterozygous phenotypes of the alpha-1-antitrypsin deficiency.

Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota

Additional Information
Alpha-1-Antitrypsin Phenotype, Serum

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.