| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Gastrin
MessageSendout, Mayo test code: GAST
Test Code
LAB80
Alias/See Also
Gastrin, S
GAST
GAST
CPT Codes
82941
Preferred Specimen
1 mL serum from a gold serum gel tube
Patient Preparation
1. Fasting (8 hours) required
2. For 12 hours before specimen collection, do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.
3. If medically feasible, proton pump inhibitor (omeprazole, lansoprazole, dexlansoprazole, esomeprazole, pantoprazole, and rabeprazole) therapy should be discontinued 1 week before measurement of serum gastrin levels.
4. Drugs that interfere with gastrointestinal motility (eg, opioids) should be discontinued for at least 2 weeks before serum gastrin testing.
Minimum Volume
0.5 mL
Other Acceptable Specimens
Red tube
Instructions
1. If multiple specimens are collected, submit each vial under a separate order.
2. Label specimens with corresponding collection time.
3. Centrifuge at refrigerated temperature within 2 hours of collection and immediately aliquot serum into plastic vial.
2. Label specimens with corresponding collection time.
3. Centrifuge at refrigerated temperature within 2 hours of collection and immediately aliquot serum into plastic vial.
Transport Container
Plastic vial
Transport Temperature
Frozen
Specimen Stability
Frozen (preferred): 30 days
Refrigerated: 24 hours
Refrigerated: 24 hours
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis: Mild OK; Gross reject
Lipemia: Mild OK; Gross OK
Icterus: NA
Other: Nonfasting specimens
Lipemia: Mild OK; Gross OK
Icterus: NA
Other: Nonfasting specimens
Methodology
Automated Chemiluminescent Immunometric Assay
FDA Status
Approved
Setup Schedule
Monday through Friday
Report Available
1-3 days
Limitations
Isolated serum gastrin levels can only be interpreted in fasting patients; nonfasting specimens are uninterpretable.
Artifactual hypergastrinemia may be observed in fasting patients who have undergone procedures that result in temporary gastric distention or dysmotility (eg, after gastroscopy).
Kidney failure prolongs the serum half-life of gastrin and is associated with increased serum gastrin levels.
In rare cases, some individuals can develop antibodies to mouse or other animal antibodies (often referred to as human anti-mouse antibodies [HAMA] or heterophile antibodies), which may cause interference in some immunoassays. Caution should be used in interpretation of results, and the laboratory should be alerted if the result does not correlate with the clinical presentation.
Drugs that interfere with gastric acid secretion, in particular proton pump inhibitors (eg, omeprazole, pantoprazole, dexlansoprazole, lansoprazole, rabeprazole), can lead to significant elevations of serum gastrin levels often above the normal range. These drugs can be discontinued, if feasible, for at least 1 week before serum gastrin measurement in order to avoid gastrin elevation.
Drugs that interfere with gastrointestinal motility (eg, opioids) may also interfere with serum gastrin testing.
Artifactual hypergastrinemia may be observed in fasting patients who have undergone procedures that result in temporary gastric distention or dysmotility (eg, after gastroscopy).
Kidney failure prolongs the serum half-life of gastrin and is associated with increased serum gastrin levels.
In rare cases, some individuals can develop antibodies to mouse or other animal antibodies (often referred to as human anti-mouse antibodies [HAMA] or heterophile antibodies), which may cause interference in some immunoassays. Caution should be used in interpretation of results, and the laboratory should be alerted if the result does not correlate with the clinical presentation.
Drugs that interfere with gastric acid secretion, in particular proton pump inhibitors (eg, omeprazole, pantoprazole, dexlansoprazole, lansoprazole, rabeprazole), can lead to significant elevations of serum gastrin levels often above the normal range. These drugs can be discontinued, if feasible, for at least 1 week before serum gastrin measurement in order to avoid gastrin elevation.
Drugs that interfere with gastrointestinal motility (eg, opioids) may also interfere with serum gastrin testing.
Reference Range
Included with report
Clinical Significance
Investigation of patients with achlorhydria or pernicious anemia.
Investigation of patients suspected of having Zollinger-Ellison syndrome.
Diagnosis of gastrinoma.
Investigation of patients suspected of having Zollinger-Ellison syndrome.
Diagnosis of gastrinoma.
Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota
Additional Information
Gastrin, Serum
