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Glucose-6-Phosphate Dehydrogenase
MessageSendout, Mayo test code: G6PD1
Test Code
LAB571
Alias/See Also
Favism
G6PD
Glucose-6-phosphate dehydrogenase
Glucose-6-phosphate dehydrogenase deficiency
Hemolytic Anemia
Nonspherocytic hemolytic anemia
CNSHA
G6PD1
G6PD
Glucose-6-phosphate dehydrogenase
Glucose-6-phosphate dehydrogenase deficiency
Hemolytic Anemia
Nonspherocytic hemolytic anemia
CNSHA
G6PD1
CPT Codes
82955
Preferred Specimen
6 mL whole blood in yellow ACD (solution B) tube
Minimum Volume
1 mL
Other Acceptable Specimens
Lavender EDTA tube or yellow ACD (solution A)
Instructions
Send specimen in original tube. Do not aliquot.
Transport Container
Original tube
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 20 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis: Reject
Methodology
Kinetic Spectrophotometry (KS)
FDA Status
Approved
Setup Schedule
Monday through Friday
Report Available
1-4 days
Limitations
During hemolytic events normal glucose 6-phosphate dehydrogenase (G6PD) activity values may be measured for several weeks following hemolysis.
Reticulocytosis from any cause can mask some G6PD deficiency cases by raising the activity level. Comparison to other red blood cell enzyme activity levels may be useful.
Recent transfusion may mask the patient's intrinsic enzyme activity and cause unreliable results.
A very high white blood cell count can cause interference and falsely raise the G6PD activity, thereby masking a deficiency, although this may be dependent on the type of white blood cell.
Reticulocytosis from any cause can mask some G6PD deficiency cases by raising the activity level. Comparison to other red blood cell enzyme activity levels may be useful.
Recent transfusion may mask the patient's intrinsic enzyme activity and cause unreliable results.
A very high white blood cell count can cause interference and falsely raise the G6PD activity, thereby masking a deficiency, although this may be dependent on the type of white blood cell.
Reference Range
Included with report
Clinical Significance
Evaluation of individuals with episodic or chronic Coombs-negative nonspherocytic hemolytic anemia.
Rapid testing to assess glucose 6-phosphate dehydrogenase (G6PD) enzyme capacity prior to rasburicase or other therapies that may cause hemolysis or methemoglobinemia in G6PD deficient patients.
May aid in the creation of a comprehensive patient profile and can ensure appropriate patient monitoring for developing anemia.
Rapid testing to assess glucose 6-phosphate dehydrogenase (G6PD) enzyme capacity prior to rasburicase or other therapies that may cause hemolysis or methemoglobinemia in G6PD deficient patients.
May aid in the creation of a comprehensive patient profile and can ensure appropriate patient monitoring for developing anemia.
Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota
Additional Information
Glucose 6-Phosphate Dehydrogenase Enzyme Activity, Blood
