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Liver-Kidney Microsomal Type 1 Antibody, IgG
MessageSendout, Mayo test code: LKM
Test Code
LAB5210396
Alias/See Also
Antibodies to Liver\Kidney Microsome Type 1, Serum
LKM1 (liver/kidney microsome type 1) antibodies
Microsomal (Liver/Kidney) Type 1 Antibodies
aLKM 1
LKM
LKM1 (liver/kidney microsome type 1) antibodies
Microsomal (Liver/Kidney) Type 1 Antibodies
aLKM 1
LKM
CPT Codes
86376
Preferred Specimen
0.5 mL serum from a gold serum gel tube
Minimum Volume
0.4 mL
Other Acceptable Specimens
Red tube
Instructions
Centrifuge and aliquot serum into a plastic vial.
Transport Container
Plastic vial
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated (preferred): 21 days
Frozen: 21 days
Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis: Reject
Gross lipemia: Reject
Gross icterus: OK
Heat treated: Reject
Gross lipemia: Reject
Gross icterus: OK
Heat treated: Reject
Methodology
Enzyme-Linked Immunosorbent Assay (ELISA)
FDA Status
Approved
Setup Schedule
Monday, Wedensday, Friday
Report Available
2-4 days
Limitations
Serologic tests for autoantibodies, including anti-liver/kidney microsomal antibodies type 1 (anti-LKM-1), should not be relied upon exclusively to determine the etiology or prognosis of patients with liver disease.
Anti-LKM-1 antibodies are not the only serological marker for autoimmune hepatitis (AIH) and should be evaluated in the context of other AIH-associated autoantibodies, including antinuclear antibodies and smooth muscle antibodies.
Anti-LKM-1 antibodies may occur in some patients with chronic hepatitis caused by hepatitis C virus (HCV) infection. Although the epitopes recognized by anti-LKM-1 antibodies in HCV infection are different than in patients with AIH type 2, physicians must use caution in interpreting the results of tests for anti-LKM-1 antibodies in such patients.
Anti-LKM-1 antibodies are not the only serological marker for autoimmune hepatitis (AIH) and should be evaluated in the context of other AIH-associated autoantibodies, including antinuclear antibodies and smooth muscle antibodies.
Anti-LKM-1 antibodies may occur in some patients with chronic hepatitis caused by hepatitis C virus (HCV) infection. Although the epitopes recognized by anti-LKM-1 antibodies in HCV infection are different than in patients with AIH type 2, physicians must use caution in interpreting the results of tests for anti-LKM-1 antibodies in such patients.
Reference Range
Included with report
Clinical Significance
Evaluation of patients with liver disease of unknown etiology
Evaluation of patients with suspected autoimmune hepatiti
Evaluation of patients with suspected autoimmune hepatiti
Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota
Additional Information
Liver/Kidney Microsome Type 1 Antibodies, Serum
