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Toxoplsma gondii Ab (IgG, IgM)
MessageSendout, Mayo test code: TXMGP
Test Code
LAB5210348
Alias/See Also
T. gondii
Toxoplasma gondii
Toxoplasma IgG & IgM Antibody Assays
Toxoplasma, IgG Antibody, Serum
Toxoplasma, IgM Antibody, Serum
Toxoplasmosis
TXMGP
Toxoplasma gondii
Toxoplasma IgG & IgM Antibody Assays
Toxoplasma, IgG Antibody, Serum
Toxoplasma, IgM Antibody, Serum
Toxoplasmosis
TXMGP
CPT Codes
83874
Includes
Toxoplasma Ab, IgG, IgM S Toxoplasma IgG Value
Preferred Specimen
1.5 mL serum from a gold serum gel tube
Minimum Volume
0.8 mL
Instructions
Centrifuge and aliquot serum into a plastic vial.
Transport Container
Plastic vial
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated (preferred): 14 days
Frozen: 14 days
Frozen: 14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis: Reject
Gross lipemia: Reject
Heat-inactivated specimen: Reject
Gross lipemia: Reject
Heat-inactivated specimen: Reject
Methodology
Multiplex Flow Immunoassay (MFI)
FDA Status
Approved
Setup Schedule
Monday through Saturday
Report Available
1-3 days
Limitations
Diagnosis of recent infection by Toxoplasma gondii can only be established by a combination of clinical and serological data.
The result of a single serum specimen does not constitute sufficient proof for diagnosis of recent infection. If a serum specimen was collected too soon after infection, IgM antibodies to T gondii may be absent. If this is suspected, a second serum specimen should be collected 2 to 3 weeks later and the test repeated.
Sera collected very early during the acute stage of infection may have Toxoplasma IgG levels below 9 IU/mL. The Toxoplasma IgG assay should not be used alone to diagnose recent T gondii infection. Results should be considered in conjunction with clinical presentation, patient history, and other laboratory findings.
Results should be interpreted with caution in patients who are either HIV-positive, receiving immunosuppressive therapy, or have other disorders leading to immunosuppression.
Heterophile antibodies in the patient specimens may interfere with the assay performance.
As with any low prevalence analyte, there is the increased possibility that a positive result may actually be false, reducing the assay's positive predictive value. Per the Public Health Advisory (07/25/1997), the US Food and Drug Administration suggests that sera found to be positive for T gondii IgM antibodies should be submitted to a Toxoplasma reference laboratory.
The performance characteristics of this assay have not been evaluated in immunocompromised individuals and have not been established for cord blood or for testing of neonates.
The result of a single serum specimen does not constitute sufficient proof for diagnosis of recent infection. If a serum specimen was collected too soon after infection, IgM antibodies to T gondii may be absent. If this is suspected, a second serum specimen should be collected 2 to 3 weeks later and the test repeated.
Sera collected very early during the acute stage of infection may have Toxoplasma IgG levels below 9 IU/mL. The Toxoplasma IgG assay should not be used alone to diagnose recent T gondii infection. Results should be considered in conjunction with clinical presentation, patient history, and other laboratory findings.
Results should be interpreted with caution in patients who are either HIV-positive, receiving immunosuppressive therapy, or have other disorders leading to immunosuppression.
Heterophile antibodies in the patient specimens may interfere with the assay performance.
As with any low prevalence analyte, there is the increased possibility that a positive result may actually be false, reducing the assay's positive predictive value. Per the Public Health Advisory (07/25/1997), the US Food and Drug Administration suggests that sera found to be positive for T gondii IgM antibodies should be submitted to a Toxoplasma reference laboratory.
The performance characteristics of this assay have not been evaluated in immunocompromised individuals and have not been established for cord blood or for testing of neonates.
Reference Range
Included with report
Clinical Significance
Determining whether a patient has had previous exposure to or recent infection with Toxoplasma gondii
IgG is not useful for diagnosing infection in infants younger than 6 months of age. IgG antibodies in this age group usually are the result of passive transfer from the mother.
IgG is not useful for diagnosing infection in infants younger than 6 months of age. IgG antibodies in this age group usually are the result of passive transfer from the mother.
Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota
Additional Information
Toxoplasma gondii Antibody, IgM and IgG, Serum
