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Toxoplasma gondii Antibody, IgM
MessageSendout, Mayo test code: TXM
Test Code
LAB659
Alias/See Also
T. gondii
Toxoplasma gondii
Toxoplasma IgM Antibody Assay
Toxoplasmosis
Torch
TorC
TXM
Toxoplasma gondii
Toxoplasma IgM Antibody Assay
Toxoplasmosis
Torch
TorC
TXM
CPT Codes
86778
Preferred Specimen
1 mL serum from a gold serum separator tube (SST)
Minimum Volume
0.8 mL
Other Acceptable Specimens
Red tube
Instructions
Centrifuge and aliquot serum into a plastic vial.
Transport Container
Plastic vial
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated (preferred): 14 days
Frozen: 14 days
Frozen: 14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis: Reject
Gross lipemia: Reject
Heat-inactivated specimen: Reject
Gross lipemia: Reject
Heat-inactivated specimen: Reject
Methodology
Enzyme Immunoassay (EIA)
FDA Status
Approved
Setup Schedule
Monday through Saturday
Report Available
1-3 days
Limitations
Diagnosis of recent infection by Toxoplasma gondii can only be established on the basis of a combination of clinical and serological data.
The result of a single serum sample does not constitute sufficient proof for diagnosis of recent infection.
If a serum specimen was collected too soon after infection, IgM antibodies to Toxoplasma gondii may be absent. If this is suspected, a second serum specimen should be collected 2 to 3 weeks later, and the test repeated.
Results should be interpreted with caution in patients who are either HIV-positive, receiving immunosuppressive therapy, or have other disorders leading to immunosuppression.
Heterophile antibodies in the patient specimens may interfere with the assay performance.
The performance of the assay has not been established for cord blood testing.
As with any low prevalence analyte, there is the increased possibility that a positive result may actually be false, reducing the assay's positive predictive value. Per the Public Health Advisory (7/25/1997), the US Food and Drug Administration suggests that sera found to be positive for Toxoplasma gondii IgM antibodies should be submitted to a Toxoplasma reference laboratory.
The result of a single serum sample does not constitute sufficient proof for diagnosis of recent infection.
If a serum specimen was collected too soon after infection, IgM antibodies to Toxoplasma gondii may be absent. If this is suspected, a second serum specimen should be collected 2 to 3 weeks later, and the test repeated.
Results should be interpreted with caution in patients who are either HIV-positive, receiving immunosuppressive therapy, or have other disorders leading to immunosuppression.
Heterophile antibodies in the patient specimens may interfere with the assay performance.
The performance of the assay has not been established for cord blood testing.
As with any low prevalence analyte, there is the increased possibility that a positive result may actually be false, reducing the assay's positive predictive value. Per the Public Health Advisory (7/25/1997), the US Food and Drug Administration suggests that sera found to be positive for Toxoplasma gondii IgM antibodies should be submitted to a Toxoplasma reference laboratory.
Reference Range
Included with report
Clinical Significance
Detecting recent infection with Toxoplasma gondii
Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota
Additional Information
Toxoplasma gondii Antibody, IgM, Serum
