| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
NT-PRO BNP
MessageChemistry
Test Code
LAB5210589
Alias/See Also
Pro BNP
CPT Codes
83880
Includes
N-Terminal Pro b-Type natriuretic Peptide
Preferred Specimen
Light green top tube (lithium heparin plasma)
Minimum Volume
Whole blood: 700 uL (one full light-green-top microtainer or two full red-top microtainers).
Serum/plasma: 300 uL.
Serum/plasma: 300 uL.
Other Acceptable Specimens
Gold top (serum separator tube) or Red Top
Instructions
LAB: BNP testing is performed on plasma.
Specimen Stability
Ambient: 24 hours.
Refrigerated: 4 days.
Frozen: 26 weeks.
Refrigerated: 4 days.
Frozen: 26 weeks.
FDA Status
Approved
Setup Schedule
Everyday
Report Available
Same day
Reference Range
Include Normal (age, male, female) and Linearity ranges:
Comment (0-21 years):
Clinical performance and reference ranges have not been established for this patient population.
Comment (22-49 years):
For ED patients with dyspnea and clinical suspicion of heart failure:
For outpatients with clinical suspicion of heart failure:
Comment (50-74 years):
For ED patients with dyspnea and clinical suspicion of heart failure:
For outpatients with clinical suspicion of heart failure:
Comment (75+ years):
For ED patients with dyspnea and clinical suspicion of heart failure:
For outpatients with clinical suspicion of heart failure:
Comment (>110 years old):
For ED patients with dyspnea and clinical suspicion of heart failure:
For outpatients ≥ 22 years old* with clinical suspicion of heart failure:
Comment (0-21 years):
Clinical performance and reference ranges have not been established for this patient population.
Comment (22-49 years):
For ED patients with dyspnea and clinical suspicion of heart failure:
| NT-proBNP (pg/mL) | Interpretation |
| <300 | Negative: Heart failure unlikely |
| 300 - 449 | Indeterminate: Consider other causes of NT-proBNP elevation |
| ≥450 | Positive: Heart failure likely |
| NT-proBNP (pg/mL) | Interpretation |
| <125 | Negative: Heart failure unlikely |
| ≥125 | Consider heart failure as well as other causes of NT-proBNP elevation |
Comment (50-74 years):
For ED patients with dyspnea and clinical suspicion of heart failure:
| NT-proBNP (pg/mL) | Interpretation |
| <300 | Negative: Heart failure unlikely |
| 300 - 899 | Indeterminate: Consider other causes of NT-proBNP elevation |
| ≥900 | Positive: Heart failure likely |
For outpatients with clinical suspicion of heart failure:
| NT-proBNP (pg/mL) | Interpretation |
| <125 | Negative: Heart failure unlikely |
| ≥125 | Consider heart failure as well as other causes of NT-proBNP elevation |
For ED patients with dyspnea and clinical suspicion of heart failure:
| NT-proBNP (pg/mL) | Interpretation |
| <300 | Negative: Heart failure unlikely |
| 300 – 1799 | Indeterminate: Consider other causes of NT-proBNP elevation |
| ≥1800 | Positive: Heart failure likely |
For outpatients with clinical suspicion of heart failure:
| NT-proBNP (pg/mL) | Interpretation |
| <125 | Negative: Heart failure unlikely |
| ≥125 | Consider heart failure as well as other causes of NT-proBNP elevation |
Comment (>110 years old):
For ED patients with dyspnea and clinical suspicion of heart failure:
| NT-proBNP (pg/mL) | Patient age (years)* | Interpretation |
| < 300 | ≥ 22 | Negative: Heart failure unlikely |
| 300 - 449 | 22 - 49 | Indeterminate: Consider other causes of NT-proBNP elevation |
| 300 - 899 | 50 - 74 | |
| 300 - 1799 | ≥ 75 | |
| ≥ 450 | 22 - 49 | Positive: Heart failure likely |
| ≥ 900 | 50 - 74 | |
| ≥ 1800 | ≥ 75 |
For outpatients ≥ 22 years old* with clinical suspicion of heart failure:
| NT-proBNP (pg/mL) | Interpretation |
| < 125 | Negative: Heart failure unlikely |
| ≥ 125 | Consider heart failure as well as other causes of NT-proBNP elevation |
Performing Laboratory
Hoag Newport/ Hoag Irvine
