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Myoglobin, Urine
MessageSendout, Mayo test code: MYGLU
Test Code
LAB412
Alias/See Also
MYGLU
CPT Codes
83874
Preferred Specimen
5 mL random urine in a sterile container
Minimum Volume
1 mL
Instructions
1. Collect a preservative-free, random urine specimen.
2. If specimen is at ambient temperature, aliquot the urine to a urine myoglobin transport tube (T691) within 1 hour of collection. Refrigerate specimen.
3. If specimen is refrigerate, aliquot the urine to a urine myoglobin transport tube (T691) within 2 hours of collection.
Additional Information: Urinary myoglobin is highly unstable unless alkalinized with sodium carbonate preservative. Even with alkalinization, myoglobin deterioration is variable and specimen dependent (approximate averages of 10% at 1 day, 20% at 3 days, and 30% at 7 days).
2. If specimen is at ambient temperature, aliquot the urine to a urine myoglobin transport tube (T691) within 1 hour of collection. Refrigerate specimen.
3. If specimen is refrigerate, aliquot the urine to a urine myoglobin transport tube (T691) within 2 hours of collection.
Additional Information: Urinary myoglobin is highly unstable unless alkalinized with sodium carbonate preservative. Even with alkalinization, myoglobin deterioration is variable and specimen dependent (approximate averages of 10% at 1 day, 20% at 3 days, and 30% at 7 days).
Transport Container
Plastic, 10-mL urine myoglobin transport tube
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated: 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Use of any transport tube other than urine myoglobin transport tube
Methodology
Latex Particle-Enhanced Immunoturbidometric Assay
FDA Status
Approved
Setup Schedule
Monday through Sunday
Report Available
1-2 days
Limitations
Elevated myoglobin concentration has been observed in patients experiencing skeletal muscle trauma, renal failure, and certain chronic heart pathologies, and after strenous exercise. Heterophile antibodies in serum or plasma sample may cause interferences in immunoassays.
Reference Range
An elevated level of myoglobin in urine does not identify the clinical disorder.
Urine collected with acid as preservative will not be valid because acid interferes with analyte integrity.
Urinary myoglobin deteriorates rapidly unless stabilized immediately after collection by alkalizing with sodium carbonate.
Urinary myoglobin does not withstand freezing even when pH is raised with sodium carbonate.
Urine collected with acid as preservative will not be valid because acid interferes with analyte integrity.
Urinary myoglobin deteriorates rapidly unless stabilized immediately after collection by alkalizing with sodium carbonate.
Urinary myoglobin does not withstand freezing even when pH is raised with sodium carbonate.
Clinical Significance
Confirming the presence of a myopathy associated with any 1 of the following disorders
-Hereditary myoglobinuria
-Phosphorylase deficiency
-Sporadic myoglobinuria
-Exertional myoglobinuria in untrained individuals
-Crush syndrome
-Myocardial infarction
-Myoglobinuria of progressive muscle disease
-Heat injury
May suggest a myopathic cause for acute renal failure
-Hereditary myoglobinuria
-Phosphorylase deficiency
-Sporadic myoglobinuria
-Exertional myoglobinuria in untrained individuals
-Crush syndrome
-Myocardial infarction
-Myoglobinuria of progressive muscle disease
-Heat injury
May suggest a myopathic cause for acute renal failure
Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota
Additional Information
Myoglobin, Random, Urine
