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EOSINOPHIL SMEAR, URINE
MessageUrinalysis
Test Code
LAB5210703
Alias/See Also
Eosinophil Urine
EOSUR
UREOS
UEOS
EOS
EOSUR
UREOS
UEOS
EOS
CPT Codes
89190
Preferred Specimen
20 mL of clean catch midstream urine specimen in sterile, non-preservative container
Minimum Volume
10 mL
Instructions
LAB: Pour off separate aliquot for EOSUR
If ordered with Urinalysis testing, aliquot separate samples for each test.
If ordered with Urinalysis testing, aliquot separate samples for each test.
Specimen Stability
Ambient: 2 hours in non-preservative, sterile container
Refrigerated (2 – 8°C): 4 hours in non-preservative, sterile container
Refrigerated urine should be brought to room temperature prior to mixing and smear preparation
Refrigerated (2 – 8°C): 4 hours in non-preservative, sterile container
Refrigerated urine should be brought to room temperature prior to mixing and smear preparation
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Quantity Not Sufficient
Specimen contamination with fecal material
Specimen contamination with fecal material
Methodology
Wright's stain for WBC staining and Eosinophilic differentiation
Setup Schedule
Same day.
Limitations
Eosinophils are not always present or prominent in interstitial nephritis and may be sparse in instances of that disease group.
NOTES:
No relationship is known between eosinophiluria and peripheral blood eosinophilia.
In only a third of cases of drug-induced acute interstitial nephritis is the complete syndrome present. The complete syndrome includes fever, rash, and eosinophiluria with acute renal failure.
Acute interstitial nephritis relates to Penicillin derivatives, Sulfa drugs, Allopurinol, Sulfinpyrazone, Nitrofurantoin and Erythromycin. Methicillin is frequently mentioned.
Not all individuals with eosinophiluria have acute interstitial nephritis. Other diseases in which urinary eosinophilia is reported include contrast nephropathy, renal failure, glomerulonephritis, and in 45% of cases of eosinophiluria, urinary tract infection.
Albumin is a natural buffer of pH 7. It also makes superior slides because of the protein content.
NOTES:
No relationship is known between eosinophiluria and peripheral blood eosinophilia.
In only a third of cases of drug-induced acute interstitial nephritis is the complete syndrome present. The complete syndrome includes fever, rash, and eosinophiluria with acute renal failure.
Acute interstitial nephritis relates to Penicillin derivatives, Sulfa drugs, Allopurinol, Sulfinpyrazone, Nitrofurantoin and Erythromycin. Methicillin is frequently mentioned.
Not all individuals with eosinophiluria have acute interstitial nephritis. Other diseases in which urinary eosinophilia is reported include contrast nephropathy, renal failure, glomerulonephritis, and in 45% of cases of eosinophiluria, urinary tract infection.
Albumin is a natural buffer of pH 7. It also makes superior slides because of the protein content.
Reference Range
None seen
Clinical Significance
Eosinophils are found in large numbers in the urine of patients with interstitial nephritis, eosinophilic cystitis, and other entities. Tubulointerstitial disease is associated with hypersensitivity to drugs such as Penicillin and its analogues. The cell pattern in allergic interstitial nephritis usually includes many red blood cells and some renal tubular epithelial cells as well as eosinophils.
Performing Laboratory
HHN / HHI Laboratory
